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J. Biophys. and Biochem. Cytol., Vol 1, 119-126, Copyright © 1955 by Rockefeller University Press

ARTICLE

ANTAGONISTIC EFFECTS OF 6-MERCAPTOPURINE AND COENZYME A ON MITOCHONDRIA AND MITOSIS IN TISSUE CULTURE

John J. Biesele Ph.D.1

1 (From the Cell Growth Section, Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, and the Sloan-Kettering Division, Cornell University Graduate School of Medical Sciences, New York)

The partial mitotic inhibition caused by 6-mercaptopurine in tissue cultures of Crocker mouse sarcoma 180 and embryonic mouse skin is blocked by co-enzyme A. 6-Mercaptopurine and coenzyme A also have opposite effects on mitochondrial morphology. Mitochondria in cells treated with 6-mercaptopurine become thin and fragmented. Coenzyme A blocks this effect, and alone coenzyme A makes for longer and thicker mitochondria. 6-Mercaptopurine inhibits lipogenesis in embryo skin fibroblasts, and this inhibition is partly counteracted by coenzyme A, which by itself makes for a greater accumulation of lipid droplets in the cytoplasm.

It is suggested that at least one part of the action by which 6-mercaptopurine decreases mitotic incidence in tissue cultures may be an interference on the part of 6-mercaptopurine, acting as an antimetabolite of coenzyme A, in mitochondrial function related to cell division.

 Submitted on October 29, 1954


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