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J. Biophys. and Biochem. Cytol., Vol 10, 347-351, Copyright © 1961 by Rockefeller University Press

ARTICLE

FOUR-STRANDED DNA AS DETERMINED BY ELECTRON MICROSCOPY

Cecil E. Hall Ph.D.1 and Liebe F. Cavalieri Ph.D.1

1 From the Biology Department, Massachusetts Institute of Technology, Cambridge, and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York

Pneumococcus DNA, of weight-average molecular weight 1.6 million by light scattering, had a weight-average length of 4300 A by electron microscopy. Thus, the average mass per unit length was 370 molecular-weight units per A, or approximately two times that expected (208) for a Watson-Crick double helix. This corresponds to an average of 3.6 strands per molecule, which is close to that obtained by other methods. Morphologically, all the particles in the micrographs were relatively stiff, and had a cross-sectional height of 20 to 30 A. Some divided into two stiff branches of the same height, apparently double helical. Where the branches combined into one (minimally four-stranded) structure they apparently lay side by side in close association.

Submitted on March 6, 1961


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