The Journal of Cell Biology, Vol 100, 648-651, Copyright © 1985 by The Rockefeller University Press
Orthogonal arrays in normal and injured respiratory airway epithelium
RE Gordon
Orthogonal arrays are found on plasma membranes of glial cells, in the
central nervous system, on muscle plasma membranes at neuromuscular
junctions, and on a variety of epithelial cells. These structures have been
correlated with ion flux. With the aid of freeze fracture technique,
orthogonal particle arrays were found on plasma membranes on airway
epithelial cells of rats and hamsters. They have been found in abundance at
the base of secretory cells throughout normal airway epithelium. These
structures were found to increase in number during regeneration in response
to injury and they were found in great numbers on plasma membranes of all
airway cells in response to acute and chronic NO2 exposure. The lateral and
basal plasma membranes of the respiratory epithelium are a new source for
studying orthogonal arrays. The normal number and distribution of these
arrays can be perturbed in response to mechanical and chemical injury.
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