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The Journal of Cell Biology, Vol 105, 1267-1271, Copyright © 1987 by The Rockefeller University Press
ARTICLES |
B Kachar, PC Bridgman and TS Reese
Laboratory of Neuro-otolaryngology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Transient shape changes of organelles translocating along microtubules are directly visualized in thinly spread cytoplasmic processes of the marine foraminifer. Allogromia laticollaris, by a combination of high- resolution video-enhanced microscopy and fast-freezing electron microscopy. The interacting side of the organelle flattens upon binding to a microtubule, as if to maximize contact with it. Organelles typically assume a teardrop shape while moving, as if they were dragged through a viscous medium. Associated microtubules bend around attachments of the teardrop-shaped organelles, suggesting that they too are acted on by the forces deforming the organelles. An 18-nm gap between the organelles and the microtubules is periodically bridged by 10-nm-thick cross-bridge structures that may be responsible for the binding and motive forces deforming organelles and microtubules.
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