The Journal of Cell Biology, Vol 105, 2501-2510, Copyright © 1987 by The Rockefeller University Press

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Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles

S Hirano, A Nose, K Hatta, A Kawakami and M Takeichi
Department of Biophysics, Faculty of Science, Kyoto University, Japan.

Cadherins are a family of cell-cell adhesion molecules and are divided into subclasses with distinct adhesive specificities and tissue distribution. Here we examined the distribution of cadherins at contact sites between cells expressing the same or different cadherin subclasses. Each cadherin was concentrated at the boundary between cells expressing an identical cadherin subclass, irrespective of the cell types connected. However, such localization decreased or disappeared at the boundary between cells containing different cadherin subclasses. We also found that the localization of cadherins precisely coincided with that of actin bundles; both were detected at the apical region of cell sheets. This co-localization was retained even after cells were either treated with cytochalasin D or extracted with the detergent NP40. These results suggest that each cadherin subclass preferentially interacts with its own molecular type at intercellular boundaries, and that cadherin molecules may be associated with actin- based cytoskeletal elements.
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• Sawyer, S. J., Muscatine, L. (2002). Cellular mechanisms underlying temperature-induced bleaching in the tropical sea anemone Aiptasia pulchella. J. Exp. Biol. 204: 3443-3456 [Abstract] [Full Text]  
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• Waibler, Z., Schafer, A., Starzinski-Powitz, A. (2001). mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing. J. Cell Sci. 114: 3873-3884 [Abstract] [Full Text]  
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• Kaufmann, U, Zuppinger, C, Waibler, Z, Rudiger, M, Urbich, C, Martin, B, Jockusch, B., Eppenberger, H, Starzinski-Powitz, A (2000). The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. J. Cell Sci. 113: 4121-4135 [Abstract]  
• Troxell, M., Gopalakrishnan, S, McCormack, J, Poteat, B., Pennington, J, Garringer, S., Schneeberger, E., Nelson, W., Marrs, J. (2000). Inhibiting cadherin function by dominant mutant E-cadherin expression increases the extent of tight junction assembly. J. Cell Sci. 113: 985-996 [Abstract]  
• Quinlan, M. P., Hyatt, J. L. (1999). Establishment of the Circumferential Actin Filament Network Is a Prerequisite for Localization of the Cadherin-Catenin Complex in Epithelial Cells. Cell Growth Differ. 10: 839-854 [Abstract] [Full Text]  
• Imamura, Y., Itoh, M., Maeno, Y., Tsukita, S., Nagafuchi, A. (1999). Functional Domains of alpha -Catenin Required for the Strong State of Cadherin-based Cell Adhesion. JCB 144: 1311-1322 [Abstract] [Full Text]  
• Hirano, S., Yan, Q., Suzuki, S. T. (1999). Expression of a Novel Protocadherin, OL-Protocadherin, in a Subset of Functional Systems of the Developing Mouse Brain. J. Neurosci. 19: 995-1005 [Abstract] [Full Text]  
• Troxell, M. L., Chen, Y.-T., Cobb, N., Nelson, W. J., Marrs, J. A. (1999). Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression. Am. J. Physiol. Cell Physiol. 276: C404-C418 [Abstract] [Full Text]  
• Hayashi, K, Yonemura, S, Matsui, T, Tsukita, S (1999). Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues. J. Cell Sci. 112: 1149-1158 [Abstract]  
• Kaufmann, U, Kirsch, J, Irintchev, A, Wernig, A, Starzinski-Powitz, A (1999). The M-cadherin catenin complex interacts with microtubules in skeletal muscle cells: implications for the fusion of myoblasts. J. Cell Sci. 112: 55-68 [Abstract]  
• YEAMAN, C., GRINDSTAFF, K. K., NELSON, W. J. (1999). New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity. Physiol. Rev. 79: 73-98 [Abstract] [Full Text]  
• Ozawa, M. (1998). Identification of the Region of alpha -Catenin That Plays an Essential Role in Cadherin-mediated Cell Adhesion. J. Biol. Chem. 273: 29524-29529 [Abstract] [Full Text]  
• Pey, R., Vial, C., Schatten, G., Hafner, M. (1998). Increase of intracellular Ca2+ and relocation of E-cadherin during experimental decompaction of mouse embryos. Proc. Natl. Acad. Sci. USA 95: 12977-12982 [Abstract] [Full Text]  
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• Stewart, D. B., Nelson, W. J. (1997). Identification of Four Distinct Pools of Catenins in Mammalian Cells and Transformation-dependent Changes in Catenin Distributions among These Pools. J. Biol. Chem. 272: 29652-29662 [Abstract] [Full Text]  
• Itoh, M., Nagafuchi, A., Moroi, S., Tsukita, S. (1997). Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to alpha  Catenin and Actin Filaments. JCB 138: 181-192 [Abstract] [Full Text]  
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• Grima, J., Zhu, L.-j., Cheng, C. Y. (1997). Testin Is Tightly Associated with Testicular Cell Membrane upon Its Secretion by Sertoli Cells whose Steady-state mRNA Level in the Testis Correlates with the Turnover and Integrity of Inter-testicular Cell Junctions. J. Biol. Chem. 272: 6499-6509 [Abstract] [Full Text]  
• Barth, A. I.M., Pollack, A. L., Altschuler, Y., Mostov, K. E., Nelson, W. J. (1997). NH2-terminal Deletion of beta -Catenin Results in Stable Colocalization of Mutant beta -Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion. JCB 136: 693-706 [Abstract] [Full Text]  
• Chen, H, Paradies, N., Fedor-Chaiken, M, Brackenbury, R (1997). E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. J. Cell Sci. 110: 345-356 [Abstract]  
• Khan-Dawood, F. S., Yang, J., Dawood, M. Y. (1997). Immunohistological Localization and Expression of a-Actin in the Baboon (Papio anubis) Corpus Luteum. J. Histochem. Cytochem. 45: 71-78 [Abstract] [Full Text]  
• Takeichi, M., Uemura, T., Iwai, Y., Uchida, N., Inoue, T., Tanaka, T., Suzuki, S.C. (1997). Cadherins in Brain Patterning and Neural Network Formation. Cold Spring Harb Symp Quant Biol 62: 505-510 [Abstract]  
• Miller, J R, Moon, R T (1996). Signal transduction through beta-catenin and specification of cell fate during embryogenesis.. Genes Dev. 10: 2527-2539  
• Obata, S, Sago, H, Mori, N, Rochelle, J., Seldin, M., Davidson, M, St John, T, Taketani, S, Suzuki, S. (1995). Protocadherin Pcdh2 shows properties similar to, but distinct from, those of classical cadherins. J. Cell Sci. 108: 3765-3773 [Abstract]  
• Zeschnigk, M, Kozian, D, Kuch, C, Schmoll, M, Starzinski-Powitz, A (1995). Involvement of M-cadherin in terminal differentiation of skeletal muscle cells. J. Cell Sci. 108: 2973-2981 [Abstract]  
• Staddon, J., Herrenknecht, K, Smales, C, Rubin, L. (1995). Evidence that tyrosine phosphorylation may increase tight junction permeability. J. Cell Sci. 108: 609-619 [Abstract]  
• Yonemura, S, Itoh, M, Nagafuchi, A, Tsukita, S (1995). Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. J. Cell Sci. 108: 127-142 [Abstract]  
• Rabino, M, Trusolino, L, Prat, M, Cremona, O, Savoia, P, Marchisio, P. (1994). A monoclonal antibody identifies a novel GPI-anchored glycoprotein involved in epithelial intercellular adhesion. J. Cell Sci. 107: 1413-1428 [Abstract]  
• Levine, E, Lee, C., Kintner, C, Gumbiner, B. (1994). Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant. Development 120: 901-909 [Abstract]  
• Su, L., Vogelstein, B, Kinzler, K. (1993). Association of the APC tumor suppressor protein with catenins. Science 262: 1734-1737 [Abstract]  
• Schneider, S, Herrenknecht, K, Butz, S, Kemler, R, Hausen, P (1993). Catenins in Xenopus embryogenesis and their relation to the cadherin-mediated cell-cell adhesion system. Development 118: 629-640 [Abstract]  
• Piepenhagen, P., Nelson, W. (1993). Defining E-cadherin-associated protein complexes in epithelial cells: plakoglobin, beta- and gamma-catenin are distinct components. J. Cell Sci. 104: 751-762 [Abstract]  
• McCrea, P., Turck, C., Gumbiner, B (1991). A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254: 1359-1361 [Abstract]  
• Takeichi, M (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451-1455 [Abstract]  
• Miyatani, S, Shimamura, K, Hatta, M, Nagafuchi, A, Nose, A, Matsunaga, M, Hatta, K, Takeichi, M (1989). Neural cadherin: role in selective cell-cell adhesion. Science 245: 631-635 [Abstract]  

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