Evidence for nerve growth factor-mediated paracrine effects in human epidermis

doi:10.1083/jcb.115.3.821

This Article

	PDF (Full Text)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Yaar, M.
	Articles by Gilchrest, B. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Yaar, M.
	Articles by Gilchrest, B. A.


Social Bookmarking

	What's this?

ARTICLES

Evidence for nerve growth factor-mediated paracrine effects in human epidermis

M Yaar, K Grossman, M Eller and BA Gilchrest
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111.

Nerve growth factor (NGF) is critical to the development and maintenance of the peripheral nervous system, but its possible roles in other organ systems are less well characterized. We have recently shown that human epidermal melanocytes, pigment cells derived from the neural crest, express the NGF receptor (p75 NGF-R) in vitro (Peacocke, M., M. Yaar, C. P. Mansur, M. V. Chao, and B. A. Gilchrest. 1988. Proc. Natl. Acad. Sci. USA. 85:5282-5286). Using cultured human skin-derived cells we now demonstrate that the melanocyte p75 NGF-R is functional, in that NGF stimulation modulates melanocyte gene expression; that exposure to an NGF gradient is chemotactic for melanocytes and enhances their dendricity; and that keratinocytes, the dominant epidermal cell type, express NGF messenger RNA and hence are a possible local source of NGF for epidermal melanocytes in the skin. These combined data suggest a paracrine role for NGF in human epidermis.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Hondermarck, H. (2008). Nerve Growth Factor: The Dark Side of the Icon. Am. J. Pathol. 172: 865-867 [Abstract] [Full Text]
Costin, G.-E., Hearing, V. J. (2007). Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J. 21: 976-994 [Abstract] [Full Text]
Yazidi-Belkoura, I. E., Adriaenssens, E., Dolle, L., Descamps, S., Hondermarck, H. (2003). Tumor Necrosis Factor Receptor-associated Death Domain Protein Is Involved in the Neurotrophin Receptor-mediated Antiapoptotic Activity of Nerve Growth Factor in Breast Cancer Cells. J. Biol. Chem. 278: 16952-16956 [Abstract] [Full Text]
Besne, I., Descombes, C., Breton, L. (2002). Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis. Arch Dermatol 138: 1445-1450 [Abstract] [Full Text]
Cupp, A. S., Tessarollo, L., Skinner, M. K. (2002). Testis Developmental Phenotypes in Neurotropin Receptor trkA and trkC Null Mutations: Role in Formation of Seminiferous Cords and Germ Cell Survival. Biol. Reprod. 66: 1838-1845 [Abstract] [Full Text]
Touhami, A., Grueterich, M., Tseng, S. C. G. (2002). The Role of NGF Signaling in Human Limbal Epithelium Expanded by Amniotic Membrane Culture. IOVS 43: 987-994 [Abstract] [Full Text]
Hondermarck, H. (2000). Potential Role for NGF in Breast Cancer. Stem Cells 18: 386-387 [Full Text]
GOUKASSIAN, D., GAD, F., YAAR, M., ELLER, M. S., NEHAL, U. S., GILCHREST, B. A. (2000). Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J. 14: 1325-1334 [Abstract] [Full Text]
Levine, E., Cupp, A. S., Skinner, M. K. (2000). Role of Neurotropins in Rat Embryonic Testis Morphogenesis (Cord Formation). Biol. Reprod. 62: 132-142 [Abstract] [Full Text]
Descamps, S., Lebourhis, X., Delehedde, M., Boilly, B., Hondermarck, H. (1998). Nerve Growth Factor Is Mitogenic for Cancerous but Not Normal Human Breast Epithelial Cells. J. Biol. Chem. 273: 16659-16662 [Abstract] [Full Text]
Sensebe, L., Deschaseaux, M., Li, J., Herve, P., Charbord, P. (1997). The Broad Spectrum of Cytokine Gene Expression by Myoid Cells from the Human Marrow Microenvironment. Stem Cells 15: 133-143 [Abstract] [Full Text]
De Luca, M, Siegrist, W, Bondanza, S, Mathor, M, Cancedda, R, Eberle, A. (1993). Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors. J. Cell Sci. 105: 1079-1084 [Abstract]
Zambruno, G, Marchisio, P., Melchiori, A, Bondanza, S, Cancedda, R, De Luca, M (1993). Expression of integrin receptors and their role in adhesion, spreading and migration of normal human melanocytes. J. Cell Sci. 105: 179-190 [Abstract]
Descamps, S., Toillon, R.-A., Adriaenssens, E., Pawlowski, V., Cool, S. M., Nurcombe, V., Le Bourhis, X., Boilly, B., Peyrat, J.-P., Hondermarck, H. (2001). Nerve Growth Factor Stimulates Proliferation and Survival of Human Breast Cancer Cells through Two Distinct Signaling Pathways. J. Biol. Chem. 276: 17864-17870 [Abstract] [Full Text]