Occludin: a novel integral membrane protein localizing at tight junctions

doi:10.1083/jcb.123.6.1777

Quantitative Colocalization Analysis Software

This Article

	Full Text (PDF, 3399K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Furuse, M.
	Articles by Tsukita, S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Furuse, M.
	Articles by Tsukita, S.


Social Bookmarking

	What's this?

ARTICLES

Occludin: a novel integral membrane protein localizing at tight junctions

M Furuse, T Hirase, M Itoh, A Nagafuchi, S Yonemura, S Tsukita and S Tsukita
Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan.

Recently, we found that ZO-1, a tight junction-associated protein, was concentrated in the so called isolated adherens junction fraction from the liver (Itoh, M., A. Nagafuchi, S. Yonemura, T. Kitani-Yasuda, Sa. Tsukita, and Sh. Tsukita. 1993. J. Cell Biol. 121:491-502). Using this fraction derived from chick liver as an antigen, we obtained three monoclonal antibodies specific for a approximately 65-kD protein in rats. This antigen was not extractable from plasma membranes without detergent, suggesting that it is an integral membrane protein. Immunofluorescence and immunoelectron microscopy with these mAbs showed that this approximately 65-kD membrane protein was exclusively localized at tight junctions of both epithelial and endothelial cells: at the electron microscopic level, the labels were detected directly over the points of membrane contact in tight junctions. To further clarify the nature and structure of this membrane protein, we cloned and sequenced its cDNA. We found that the cDNA encoded a 504-amino acid polypeptide with 55.9 kDa. A search of the data base identified no proteins with significant homology to this membrane protein. A most striking feature of its primary structure was revealed by a hydrophilicity plot: four putative membrane-spanning segments were included in the NH2-terminal half. This hydrophilicity plot was very similar to that of connexin, an integral membrane protein in gap junctions. These findings revealed that an integral membrane protein localizing at tight junctions is now identified, which we designated as "occludin."
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Maria, O. M., Kim, J.-W. M., Gerstenhaber, J. A., Baum, B. J., Tran, S. D. (2008). Distribution of Tight Junction Proteins in Adult Human Salivary Glands. J. Histochem. Cytochem. 56: 1093-1098 [Abstract] [Full Text]
Baker, O. J., Camden, J. M., Redman, R. S., Jones, J. E., Seye, C. I., Erb, L., Weisman, G. A. (2008). Proinflammatory cytokines tumor necrosis factor-{alpha} and interferon-{gamma} alter tight junction structure and function in the rat parotid gland Par-C10 cell line. Am. J. Physiol. Cell Physiol. 295: C1191-C1201 [Abstract] [Full Text]
Fasano, A. (2008). Physiological, Pathological, and Therapeutic Implications of Zonulin-Mediated Intestinal Barrier Modulation: Living Life on the Edge of the Wall. Am. J. Pathol. 173: 1243-1252 [Abstract] [Full Text]
Ikenouchi, J., Sasaki, H., Tsukita, S., Furuse, M., Tsukita, S. (2008). Loss of Occludin Affects Tricellular Localization of Tricellulin. Mol. Biol. Cell 19: 4687-4693 [Abstract] [Full Text]
Shen, L., Weber, C. R., Turner, J. R. (2008). The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. JCB 181: 683-695 [Abstract] [Full Text]
Nevala, H, Ylikomi, T, Tahti, H (2008). Evaluation of the selected barrier properties of retinal pigment epithelial cell line ARPE-19 for an in-vitro blood-brain barrier model. Hum Exp Toxicol 27: 741-749 [Abstract]
Zhong, Y., Smart, E. J., Weksler, B., Couraud, P.-O., Hennig, B., Toborek, M. (2008). Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling. J. Neurosci. 28: 7788-7796 [Abstract] [Full Text]
Tarulli, G. A, Meachem, S. J, Schlatt, S., Stanton, P. G (2008). Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo. Reproduction 135: 867-877 [Abstract] [Full Text]
Teranishi, S., Kimura, K., Kawamoto, K., Nishida, T. (2008). Protection of Human Corneal Epithelial Cells from Hypoxia-Induced Disruption of Barrier Function by Keratinocyte Growth Factor. IOVS 49: 2432-2437 [Abstract] [Full Text]
Magie, C. R., Martindale, M. Q. (2008). Cell-Cell Adhesion in the Cnidaria: Insights Into the Evolution of Tissue Morphogenesis. Biol. Bull. 214: 218-232 [Abstract] [Full Text]
Amasheh, M., Schlichter, S., Amasheh, S., Mankertz, J., Zeitz, M., Fromm, M., Schulzke, J. D. (2008). Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells. J. Nutr. 138: 1067-1073 [Abstract] [Full Text]
Zhao, L., Yaoita, E., Nameta, M., Zhang, Y., Cuellar, L. M., Fujinaka, H., Xu, B., Yoshida, Y., Hatakeyama, K., Yamamoto, T. (2008). Claudin-6 localized in tight junctions of rat podocytes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R1856-R1862 [Abstract] [Full Text]
Chasiotis, H., Kelly, S. P. (2008). Occludin immunolocalization and protein expression in goldfish. J. Exp. Biol. 211: 1524-1534 [Abstract] [Full Text]
Suzuki, T., Seth, A., Rao, R. (2008). Role of Phospholipase C{gamma}-induced Activation of Protein Kinase C{epsilon} (PKC{epsilon}) and PKC{beta}I in Epidermal Growth Factor-mediated Protection of Tight Junctions from Acetaldehyde in Caco-2 Cell Monolayers. J. Biol. Chem. 283: 3574-3583 [Abstract] [Full Text]
Van Itallie, C. M., Holmes, J., Bridges, A., Gookin, J. L., Coccaro, M. R., Proctor, W., Colegio, O. R., Anderson, J. M. (2008). The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J. Cell Sci. 121: 298-305 [Abstract] [Full Text]
Yamamoto, M., Ramirez, S. H., Sato, S., Kiyota, T., Cerny, R. L., Kaibuchi, K., Persidsky, Y., Ikezu, T. (2008). Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells. Am. J. Pathol. 172: 521-533 [Abstract] [Full Text]
Piontek, J., Winkler, L., Wolburg, H., Muller, S. L., Zuleger, N., Piehl, C., Wiesner, B., Krause, G., Blasig, I. E. (2008). Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J. 22: 146-158 [Abstract] [Full Text]
Sun, X., Yang, H., Nose, K., Nose, S., Haxhija, E. Q., Koga, H., Feng, Y., Teitelbaum, D. H. (2008). Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G139-G147 [Abstract] [Full Text]
Wu, J., Yang, Y., Zhang, J., Ji, P., Du, W., Jiang, P., Xie, D., Huang, H., Wu, M., Zhang, G., Wu, J., Shi, Y. (2007). Domain-swapped Dimerization of the Second PDZ Domain of ZO2 May Provide a Structural Basis for the Polymerization of Claudins. J. Biol. Chem. 282: 35988-35999 [Abstract] [Full Text]
Moser, L. A., Carter, M., Schultz-Cherry, S. (2007). Astrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication. J. Virol. 81: 11937-11945 [Abstract] [Full Text]
Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P.-O., Piontek, J., Blasig, I. E., Dijkstra, C. D., Ronken, E., de Vries, H. E. (2007). Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J. 21: 3666-3676 [Abstract] [Full Text]
Failor, K. L., Desyatnikov, Y., Finger, L. A., Firestone, G. L. (2007). Glucocorticoid-Induced Degradation of Glycogen Synthase Kinase-3 Protein Is Triggered by Serum- and Glucocorticoid-Induced Protein Kinase and Akt Signaling and Controls {beta}-Catenin Dynamics and Tight Junction Formation in Mammary Epithelial Tumor Cells. Mol. Endocrinol. 21: 2403-2415 [Abstract] [Full Text]
Behling-Kelly, E., McClenahan, D., Kim, K. S., Czuprynski, C. J. (2007). Viable "Haemophilus somnus" Induces Myosin Light-Chain Kinase-Dependent Decrease in Brain Endothelial Cell Monolayer Resistance. Infect. Immun. 75: 4572-4581 [Abstract] [Full Text]
Beau, I., Cotte-Laffitte, J., Amsellem, R., Servin, A. L. (2007). A Protein Kinase A-Dependent Mechanism by Which Rotavirus Affects the Distribution and mRNA Level of the Functional Tight Junction-Associated Protein, Occludin, in Human Differentiated Intestinal Caco-2 Cells. J. Virol. 81: 8579-8586 [Abstract] [Full Text]
Wanner, S. J., Miller, J. R. (2007). Regulation of otic vesicle and hair cell stereocilia morphogenesis by Ena/VASP-like (Evl) in Xenopus. J. Cell Sci. 120: 2641-2651 [Abstract] [Full Text]
Tokunaga, Y., Kojima, T., Osanai, M., Murata, M., Chiba, H., Tobioka, H., Sawada, N. (2007). A Novel Monoclonal Antibody Against the Second Extracellular Loop of Occludin Disrupts Epithelial Cell Polarity. J. Histochem. Cytochem. 55: 735-744 [Abstract] [Full Text]
Kohler, H., Sakaguchi, T., Hurley, B. P., Kase, B. J., Reinecker, H.-C., McCormick, B. A. (2007). Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G178-G187 [Abstract] [Full Text]
Laurila, J. J., Karttunen, T., Koivukangas, V., Laurila, P. A., Syrjala, H., Saarnio, J., Soini, Y., Ala-Kokko, T. I. (2007). Tight Junction Proteins in Gallbladder Epithelium: Different Expression in Acute Acalculous and Calculous Cholecystitis. J. Histochem. Cytochem. 55: 567-573 [Abstract] [Full Text]
Kaitu'u-Lino, T. J, Sluka, P., Foo, C. F H, Stanton, P. G (2007). Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro. Reproduction 133: 1169-1179 [Abstract] [Full Text]
Meyers, J. R., Corwin, J. T. (2007). Shape Change Controls Supporting Cell Proliferation in Lesioned Mammalian Balance Epithelium. J. Neurosci. 27: 4313-4325 [Abstract] [Full Text]
Blikslager, A. T., Moeser, A. J., Gookin, J. L., Jones, S. L., Odle, J. (2007). Restoration of Barrier Function in Injured Intestinal Mucosa. Physiol. Rev. 87: 545-564 [Abstract] [Full Text]
Sugihara-Mizuno, Y., Adachi, M., Kobayashi, Y., Hamazaki, Y., Nishimura, M., Imai, T., Furuse, M., Tsukita, S. (2007). Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. GENES CELLS 12: 473-486 [Abstract] [Full Text]
Koto, T., Takubo, K., Ishida, S., Shinoda, H., Inoue, M., Tsubota, K., Okada, Y., Ikeda, E. (2007). Hypoxia Disrupts the Barrier Function of Neural Blood Vessels through Changes in the Expression of Claudin-5 in Endothelial Cells. Am. J. Pathol. 170: 1389-1397 [Abstract] [Full Text]
Bendfeldt, K., Radojevic, V., Kapfhammer, J., Nitsch, C. (2007). Basic Fibroblast Growth Factor Modulates Density of Blood Vessels and Preserves Tight Junctions in Organotypic Cortical Cultures of Mice: A New In Vitro Model of the Blood-Brain Barrier. J. Neurosci. 27: 3260-3267 [Abstract] [Full Text]
Shi, L. Z., Zheng, W. (2007). Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro. Hum Exp Toxicol 26: 159-167 [Abstract]
Massey-Harroche, D., Delgrossi, M.-H., Lane-Guermonprez, L., Arsanto, J.-P., Borg, J.-P., Billaud, M., Le Bivic, A. (2007). Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex. Hum Mol Genet 16: 529-536 [Abstract] [Full Text]
Gopalakrishnan, S., Hallett, M. A., Atkinson, S. J., Marrs, J. A. (2007). aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion. Am. J. Physiol. Cell Physiol. 292: C1094-C1102 [Abstract] [Full Text]
Sosnova-Netukova, M., Kuchynka, P., Forrester, J. V (2007). The suprabasal layer of corneal epithelial cells represents the major barrier site to the passive movement of small molecules and trafficking leukocytes. Br. J. Ophthalmol. 91: 372-378 [Abstract] [Full Text]
Brun, P., Castagliuolo, I., Leo, V. D., Buda, A., Pinzani, M., Palu, G., Martines, D. (2007). Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G518-G525 [Abstract] [Full Text]
Zeissig, S, Burgel, N, Gunzel, D, Richter, J, Mankertz, J, Wahnschaffe, U, Kroesen, A J, Zeitz, M, Fromm, M, Schulzke, J-D (2007). Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72 [Abstract] [Full Text]
Kohno, Y., Okamoto, T., Ishibe, T., Nagayama, S., Shima, Y., Nishijo, K., Shibata, K. R., Fukiage, K., Otsuka, S., Uejima, D., Araki, N., Naka, N., Nakashima, Y., Aoyama, T., Nakayama, T., Nakamura, T., Toguchida, J. (2006). Expression of Claudin7 Is Tightly Associated with Epithelial Structures in Synovial Sarcomas and Regulated by an Ets Family Transcription Factor, ELF3. J. Biol. Chem. 281: 38941-38950 [Abstract] [Full Text]
Adachi, M., Inoko, A., Hata, M., Furuse, K., Umeda, K., Itoh, M., Tsukita, S. (2006). Normal Establishment of Epithelial Tight Junctions in Mice and Cultured Cells Lacking Expression of ZO-3, a Tight-Junction MAGUK Protein. Mol. Cell. Biol. 26: 9003-9015 [Abstract] [Full Text]
Bentz, G. L., Jarquin-Pardo, M., Chan, G., Smith, M. S., Sinzger, C., Yurochko, A. D. (2006). Human Cytomegalovirus (HCMV) Infection of Endothelial Cells Promotes Naive Monocyte Extravasation and Transfer of Productive Virus To Enhance Hematogenous Dissemination of HCMV. J. Virol. 80: 11539-11555 [Abstract] [Full Text]
Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Khazen, S., Dijkstra, C. D., de Vries, H. E. (2006). Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells. FASEB J. 20: 2550-2552 [Abstract] [Full Text]
Abuazza, G., Becker, A., Williams, S. S., Chakravarty, S., Truong, H.-T., Lin, F., Baum, M. (2006). Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins. Am. J. Physiol. Renal Physiol. 291: F1132-F1141 [Abstract] [Full Text]
Hou, J., Gomes, A. S., Paul, D. L., Goodenough, D. A. (2006). Study of Claudin Function by RNA Interference. J. Biol. Chem. 281: 36117-36123 [Abstract] [Full Text]
Guttman, J. A., Samji, F. N., Li, Y., Vogl, A. W., Finlay, B. B. (2006). Evidence that Tight Junctions Are Disrupted Due to Intimate Bacterial Contact and Not Inflammation during Attaching and Effacing Pathogen Infection In Vivo. Infect. Immun. 74: 6075-6084 [Abstract] [Full Text]
Clark, J. A., Doelle, S. M., Halpern, M. D., Saunders, T. A., Holubec, H., Dvorak, K., Boitano, S. A., Dvorak, B. (2006). Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G938-G949 [Abstract] [Full Text]
Osanai, M., Murata, M., Nishikiori, N., Chiba, H., Kojima, T., Sawada, N. (2006). Epigenetic Silencing of Occludin Promotes Tumorigenic and Metastatic Properties of Cancer Cells via Modulations of Unique Sets of Apoptosis-Associated Genes.. Cancer Res. 66: 9125-9133 [Abstract] [Full Text]
Maminishkis, A., Chen, S., Jalickee, S., Banzon, T., Shi, G., Wang, F. E., Ehalt, T., Hammer, J. A., Miller, S. S. (2006). Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue.. IOVS 47: 3612-3624 [Abstract] [Full Text]
Fujita, H., Chiba, H., Yokozaki, H., Sakai, N., Sugimoto, K., Wada, T., Kojima, T., Yamashita, T., Sawada, N. (2006). Differential Expression and Subcellular Localization of Claudin-7, -8, -12, -13, and -15 Along the Mouse Intestine. J. Histochem. Cytochem. 54: 933-944 [Abstract] [Full Text]
Liebner, S., Cavallaro, U., Dejana, E. (2006). The Multiple Languages of Endothelial Cell-to-Cell Communication. Arterioscler. Thromb. Vasc. Bio. 26: 1431-1438 [Abstract] [Full Text]
Forster, C., Waschke, J., Burek, M., Leers, J., Drenckhahn, D. (2006). Glucocorticoid effects on mouse microvascular endothelial barrier permeability are brain specific. J. Physiol. 573: 413-425 [Abstract] [Full Text]
Tarulli, G. A., Stanton, P. G., Lerchl, A., Meachem, S. J. (2006). Adult Sertoli Cells Are Not Terminally Differentiated in the Djungarian Hamster: Effect of FSH on Proliferation and Junction Protein Organization. Biol. Reprod. 74: 798-806 [Abstract] [Full Text]
Terai, T., Nishimura, N., Kanda, I., Yasui, N., Sasaki, T. (2006). JRAB/MICAL-L2 Is a Junctional Rab13-binding Protein Mediating the Endocytic Recycling of Occludin. Mol. Biol. Cell 17: 2465-2475 [Abstract] [Full Text]
Balkovetz, D. F. (2006). Claudins at the gate: determinants of renal epithelial tight junction paracellular permeability. Am. J. Physiol. Renal Physiol. 290: F572-F579 [Abstract] [Full Text]
Zhu, L., Li, X., Zeng, R., Gorodeski, G. I. (2006). Changes in Tight Junctional Resistance of the Cervical Epithelium Are Associated with Modulation of Content and Phosphorylation of Occludin 65-Kilodalton and 50-Kilodalton Forms. Endocrinology 147: 977-989 [Abstract] [Full Text]
Everett, R. S., Vanhook, M. K., Barozzi, N., Toth, I., Johnson, L. G. (2006). Specific Modulation of Airway Epithelial Tight Junctions by Apical Application of an Occludin Peptide. Mol. Pharmacol. 69: 492-500 [Abstract] [Full Text]
DeMaio, L., Rouhanizadeh, M., Reddy, S., Sevanian, A., Hwang, J., Hsiai, T. K. (2006). Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 290: H674-H683 [Abstract] [Full Text]
Takeichi, M. (2006). Shoichiro Tsukita: a life exploring the molecular architecture of the tight junction. JCB 172: 321-323 [Abstract] [Full Text]
Mehta, D., Malik, A. B. (2006). Signaling Mechanisms Regulating Endothelial Permeability. Physiol. Rev. 86: 279-367 [Abstract] [Full Text]
Collins, N. T., Cummins, P. M., Colgan, O. C., Ferguson, G., Birney, Y. A., Murphy, R. P., Meade, G., Cahill, P. A. (2006). Cyclic Strain-Mediated Regulation of Vascular Endothelial Occludin and ZO-1: Influence on Intercellular Tight Junction Assembly and Function. Arterioscler. Thromb. Vasc. Bio. 26: 62-68 [Abstract] [Full Text]
Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., Tsukita, S. (2005). Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. JCB 171: 939-945 [Abstract] [Full Text]
Powell, K. (2005). Sticking it out with tight junctions. JCB 171: 916-917 [Full Text]
Fedwick, J. P., Lapointe, T. K., Meddings, J. B., Sherman, P. M., Buret, A. G. (2005). Helicobacter pylori Activates Myosin Light-Chain Kinase To Disrupt Claudin-4 and Claudin-5 and Increase Epithelial Permeability. Infect. Immun. 73: 7844-7852 [Abstract] [Full Text]
Meng, J., Holdcraft, R. W., Shima, J. E., Griswold, M. D., Braun, R. E. (2005). Androgens regulate the permeability of the blood-testis barrier. Proc. Natl. Acad. Sci. USA 102: 16696-16700 [Abstract] [Full Text]
Furuta, G. T., Nieuwenhuis, E. E. S., Karhausen, J., Gleich, G., Blumberg, R. S., Lee, J. J., Ackerman, S. J. (2005). Eosinophils alter colonic epithelial barrier function: role for major basic protein. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G890-G897 [Abstract] [Full Text]
Hou, J., Paul, D. L., Goodenough, D. A. (2005). Paracellin-1 and the modulation of ion selectivity of tight junctions. J. Cell Sci. 118: 5109-5118 [Abstract] [Full Text]
Osler, M. E., Chang, M. S., Bader, D. M. (2005). Bves modulates epithelial integrity through an interaction at the tight junction. J. Cell Sci. 118: 4667-4678 [Abstract] [Full Text]
Shen, L., Turner, J. R. (2005). Actin Depolymerization Disrupts Tight Junctions via Caveolae-mediated Endocytosis. Mol. Biol. Cell 16: 3919-3936 [Abstract] [Full Text]
Masuyama, A., Kondoh, M., Seguchi, H., Takahashi, A., Harada, M., Fujii, M., Mizuguchi, H., Horiguchi, Y., Watanabe, Y. (2005). Role of N-Terminal Amino Acids in the Absorption-Enhancing Effects of the C-Terminal Fragment of Clostridium perfringens Enterotoxin. J. Pharmacol. Exp. Ther. 314: 789-795 [Abstract] [Full Text]
Hawkins, B. T., Davis, T. P. (2005). The Blood-Brain Barrier/Neurovascular Unit in Health and Disease. Pharmacol. Rev. 57: 173-185 [Abstract] [Full Text]
Matlin, K. S. (2005). Clues to occludin. Focus on "Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells". Am. J. Physiol. Cell Physiol. 288: C1191-C1192 [Full Text]
Guo, X., Rao, J. N., Liu, L., Zou, T., Keledjian, K. M., Boneva, D., Marasa, B. S., Wang, J.-Y. (2005). Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G1159-G1169 [Abstract] [Full Text]
Yu, A. S. L., McCarthy, K. M., Francis, S. A., McCormack, J. M., Lai, J., Rogers, R. A., Lynch, R. D., Schneeberger, E. E. (2005). Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells. Am. J. Physiol. Cell Physiol. 288: C1231-C1241 [Abstract] [Full Text]
Miyamoto, T., Morita, K., Takemoto, D., Takeuchi, K., Kitano, Y., Miyakawa, T., Nakayama, K., Okamura, Y., Sasaki, H., Miyachi, Y., Furuse, M., Tsukita, S. (2005). Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. JCB 169: 527-538 [Abstract] [Full Text]
Takano, K.-i., Kojima, T., Go, M., Murata, M., Ichimiya, S., Himi, T., Sawada, N. (2005). HLA-DR- and CD11c-positive Dendritic Cells Penetrate beyond Well-developed Epithelial Tight Junctions in Human Nasal Mucosa of Allergic Rhinitis. J. Histochem. Cytochem. 53: 611-619 [Abstract] [Full Text]
Lowery, L. A., Sive, H. (2005). Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products. Development 132: 2057-2067 [Abstract] [Full Text]
Rothen-Rutishauser, B. M., Kiama, S. G., Gehr, P. (2005). A Three-Dimensional Cellular Model of the Human Respiratory Tract to Study the Interaction with Particles. Am. J. Respir. Cell Mol. Bio. 32: 281-289 [Abstract] [Full Text]
Wells, W. A. (2005). Defining junctional complexes. JCB 168: 989-989 [Full Text]
Yoshii, T., Mizuno, K., Hirose, T., Nakajima, A., Sekihara, H., Ohno, S. (2005). sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G564-G570 [Abstract] [Full Text]
Kondoh, M., Masuyama, A., Takahashi, A., Asano, N., Mizuguchi, H., Koizumi, N., Fujii, M., Hayakawa, T., Horiguchi, Y., Watanbe, Y. (2005). A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator. Mol. Pharmacol. 67: 749-756 [Abstract] [Full Text]
Morimoto, S., Nishimura, N., Terai, T., Manabe, S., Yamamoto, Y., Shinahara, W., Miyake, H., Tashiro, S., Shimada, M., Sasaki, T. (2005). Rab13 Mediates the Continuous Endocytic Recycling of Occludin to the Cell Surface. J. Biol. Chem. 280: 2220-2228 [Abstract] [Full Text]
Van Itallie, C. M., Anderson, J. M. (2004). The Molecular Physiology of Tight Junction Pores. Physiology 19: 331-338 [Abstract] [Full Text]
Bordin, M., D'Atri, F., Guillemot, L., Citi, S. (2004). Histone Deacetylase Inhibitors Up-Regulate the Expression of Tight Junction Proteins. Mol Cancer Res 2: 692-701 [Abstract] [Full Text]
Thomas, F. C., Sheth, B., Eckert, J. J., Bazzoni, G., Dejana, E., Fleming, T. P. (2004). Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo. J. Cell Sci. 117: 5599-5608 [Abstract] [Full Text]
McLaughlin, J., Padfield, P. J., Burt, J. P. H., O'Neill, C. A. (2004). Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms. Am. J. Physiol. Cell Physiol. 287: C1412-C1417 [Abstract] [Full Text]
Ohnishi, H., Nakahara, T., Furuse, K., Sasaki, H., Tsukita, S., Furuse, M. (2004). JACOP, a Novel Plaque Protein Localizing at the Apical Junctional Complex with Sequence Similarity to Cingulin. J. Biol. Chem. 279: 46014-46022 [Abstract] [Full Text]
Umeda, K., Matsui, T., Nakayama, M., Furuse, K., Sasaki, H., Furuse, M., Tsukita, S. (2004). Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1. J. Biol. Chem. 279: 44785-44794 [Abstract] [Full Text]
Kitajiri, S.-i., Miyamoto, T., Mineharu, A., Sonoda, N., Furuse, K., Hata, M., Sasaki, H., Mori, Y., Kubota, T., Ito, J., Furuse, M., Tsukita, S. (2004). Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. J. Cell Sci. 117: 5087-5096 [Abstract] [Full Text]
Cereijido, M., Contreras, R. G., Shoshani, L. (2004). Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans. Physiol. Rev. 84: 1229-1262 [Abstract] [Full Text]
Li, N., Lewis, P., Samuelson, D., Liboni, K., Neu, J. (2004). Glutamine regulates Caco-2 cell tight junction proteins. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G726-G733 [Abstract] [Full Text]
Pummi, K. P., Heape, A. M., Grenman, R. A., Peltonen, J. T.K., Peltonen, S. A. (2004). Tight Junction Proteins ZO-1, Occludin, and Claudins in Developing and Adult Human Perineurium. J. Histochem. Cytochem. 52: 1037-1046 [Abstract] [Full Text]
Bruewer, M., Hopkins, A. M., Hobert, M. E., Nusrat, A., Madara, J. L. (2004). RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am. J. Physiol. Cell Physiol. 287: C327-C335 [Abstract] [Full Text]
Acharya, P., Beckel, J., Ruiz, W. G., Wang, E., Rojas, R., Birder, L., Apodaca, G. (2004). Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Am. J. Physiol. Renal Physiol. 287: F305-F318 [Abstract] [Full Text]
Talavera, D., Castillo, A. M., Dominguez, M. C., Gutierrez, A. E., Meza, I. (2004). IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers. J. Gen. Virol. 85: 1801-1813 [Abstract] [Full Text]
Bazzoni, G., Dejana, E. (2004). Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis. Physiol. Rev. 84: 869-901 [Abstract] [Full Text]
Zhu, Y., Maric, J., Nilsson, M., Brannstrom, M., Janson, P.-O., Sundfeldt, K. (2004). Formation and Barrier Function of Tight Junctions in Human Ovarian Surface Epithelium. Biol. Reprod. 71: 53-59 [Abstract] [Full Text]