Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells

doi:10.1083/jcb.126.4.1079

This Article

	PDF (Full Text)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ohba, M.
	Articles by Nose, K.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ohba, M.
	Articles by Nose, K.


Social Bookmarking

	What's this?

ARTICLES

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells

M Ohba, M Shibanuma, T Kuroki and K Nose
Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Japan.

TGF-beta 1 controls the expression of numerous genes, including early response and cellular matrix genes. However, the signal-transducing mechanism underlying this regulation of gene expression is not fully understood. In this study, we investigated whether redox regulation plays a role in the TGF-beta 1 signal transduction in the mouse osteoblastic cell line (MC3T3-E1). The overall intracellular oxidized state of the cells, when measured using 2',7'-dichlorofluorescin diacetate by laser-scanning confocal microscopy, was increased transiently after the addition of TGF-beta 1. This increase was abolished by the addition of oxygen radical scavengers such as catalase and N-acetylcysteine. In a variant cell line lacking the TGF-beta 1 receptor, the intracellular oxidized state was not modulated by treatment with TGF-beta 1. We then examined the expression of early growth response-1 (egr-1) gene, which is inducible by TGF-beta 1 and H2O2. Radical scavengers inhibited the induction of egr-1 by TGF-beta 1, but not that by 12-O-tetradecanoylphorbol-13 acetate. A nuclear run- on assay indicated that this inhibition was at the transcriptional level. From transient expression experiments using chloramphenicol acetyltransferase gene linked to serially deleted egr-1 gene 5'- upstream region, the CArG element in the 5' flanking region of egr-1 was identified as an essential sequence in the transcriptional activation for both TGF-beta 1 and H2O2 stimulation. These findings suggest that H2O2 acts as a mediator for the TGF-beta 1-induced transcription of egr-1 gene.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Kubo, E., Fatma, N., Akagi, Y., Beier, D. R., Singh, S. P., Singh, D. P. (2008). TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am. J. Physiol. Cell Physiol. 294: C842-C855 [Abstract] [Full Text]
Kokusho, Y., Komaru, T., Takeda, S., Takahashi, K., Koshida, R., Shirato, K., Shimokawa, H. (2007). Hydrogen Peroxide Derived From Beating Heart Mediates Coronary Microvascular Dilation During Tachycardia. Arterioscler. Thromb. Vasc. Bio. 27: 1057-1063 [Abstract] [Full Text]
Zhou, Q., Liu, L.-Z., Fu, B., Hu, X., Shi, X., Fang, J., Jiang, B.-H. (2007). Reactive oxygen species regulate insulin-induced VEGF and HIF-1{alpha} expression through the activation of p70S6K1 in human prostate cancer cells. Carcinogenesis 28: 28-37 [Abstract] [Full Text]
Jaimes, E. A., Tian, R.-X., Raij, L. (2007). Nicotine: the link between cigarette smoking and the progression of renal injury?. Am. J. Physiol. Heart Circ. Physiol. 292: H76-H82 [Abstract] [Full Text]
Madhavan, L., Ourednik, V., Ourednik, J. (2006). Increased "Vigilance" of Antioxidant Mechanisms in Neural Stem Cells Potentiates Their Capability to Resist Oxidative Stress. Stem Cells 24: 2110-2119 [Abstract] [Full Text]
Cat, B., Stuhlmann, D., Steinbrenner, H., Alili, L., Holtkotter, O., Sies, H., Brenneisen, P. (2006). Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. J. Cell Sci. 119: 2727-2738 [Abstract] [Full Text]
Hong, J. H., Moon, S. J., Byun, H. M., Kim, M. S., Jo, H., Bae, Y. S., Lee, S.-I., Bootman, M. D., Roderick, H. L., Shin, D. M., Seo, J. T. (2006). Critical Role of Phospholipase C{gamma}1 in the Generation of H2O2-evoked [Ca2+]i Oscillations in Cultured Rat Cortical Astrocytes. J. Biol. Chem. 281: 13057-13067 [Abstract] [Full Text]
Cho, S. J., Kang, M. J., Homer, R. J., Kang, H. R., Zhang, X., Lee, P. J., Elias, J. A., Lee, C. G. (2006). Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling. J. Biol. Chem. 281: 8161-8168 [Abstract] [Full Text]
Zhu, Q.-s., Xia, L., Mills, G. B., Lowell, C. A., Touw, I. P., Corey, S. J. (2006). G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood 107: 1847-1856 [Abstract] [Full Text]
Xiao, Y. Q., Freire-de-Lima, C. G., Janssen, W. J., Morimoto, K., Lyu, D., Bratton, D. L., Henson, P. M. (2006). Oxidants Selectively Reverse TGF-{beta} Suppression of Proinflammatory Mediator Production. J. Immunol. 176: 1209-1217 [Abstract] [Full Text]
Itagaki, T, Shimizu, I, Cheng, X, Yuan, Y, Oshio, A, Tamaki, K, Fukuno, H, Honda, H, Okamura, Y, Ito, S (2005). Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells. Gut 54: 1782-1789 [Abstract] [Full Text]
Cheng, J., Encarnacion, M. M. D., Warner, G. M., Gray, C. E., Nath, K. A., Grande, J. P. (2005). TGF-{beta}1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process. Am. J. Physiol. Cell Physiol. 289: C959-C970 [Abstract] [Full Text]
Fratelli, M., Goodwin, L. O., Orom, U. A., Lombardi, S., Tonelli, R., Mengozzi, M., Ghezzi, P. (2005). Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc. Natl. Acad. Sci. USA 102: 13998-14003 [Abstract] [Full Text]
Liu, K., Chi, D. S., Li, C., Hall, H. K., Milhorn, D. M., Krishnaswamy, G. (2005). HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 289: L252-L260 [Abstract] [Full Text]
Kim-Kaneyama, J.-r., Suzuki, W., Ichikawa, K., Ohki, T., Kohno, Y., Sata, M., Nose, K., Shibanuma, M. (2005). Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo. J. Cell Sci. 118: 937-949 [Abstract] [Full Text]
Moran, A. E., Carothers, A. M., Weyant, M. J., Redston, M., Bertagnolli, M. M. (2005). Carnosol Inhibits {beta}-Catenin Tyrosine Phosphorylation and Prevents Adenoma Formation in the C57BL/6J/Min/+ (Min/+) Mouse. Cancer Res. 65: 1097-1104 [Abstract] [Full Text]
Seo, J. H., Ahn, Y., Lee, S.-R., Yeo, C. Y., Hur, K. C. (2005). The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway. Mol. Biol. Cell 16: 348-357 [Abstract] [Full Text]
Mori, K., Shibanuma, M., Nose, K. (2004). Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells. Cancer Res. 64: 7464-7472 [Abstract] [Full Text]
Chang, T.-S., Cho, C.-S., Park, S., Yu, S., Kang, S. W., Rhee, S. G. (2004). Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria. J. Biol. Chem. 279: 41975-41984 [Abstract] [Full Text]
Lee, C. G., Cho, S. J., Kang, M. J., Chapoval, S. P., Lee, P. J., Noble, P. W., Yehualaeshet, T., Lu, B., Flavell, R. A., Milbrandt, J., Homer, R. J., Elias, J. A. (2004). Early Growth Response Gene 1-mediated Apoptosis Is Essential for Transforming Growth Factor {beta}1-induced Pulmonary Fibrosis. J. Exp. Med. 200: 377-389 [Abstract] [Full Text]
Nair, V. D., Yuen, T., Olanow, C. W., Sealfon, S. C. (2004). Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress. J. Biol. Chem. 279: 27494-27501 [Abstract] [Full Text]
Mazak, I., Fiebeler, A., Muller, D. N., Park, J.-K., Shagdarsuren, E., Lindschau, C., Dechend, R., Viedt, C., Pilz, B., Haller, H., Luft, F. C. (2004). Aldosterone Potentiates Angiotensin II-Induced Signaling in Vascular Smooth Muscle Cells. Circulation 109: 2792-2800 [Abstract] [Full Text]
Gooch, J. L., Gorin, Y., Zhang, B.-X., Abboud, H. E. (2004). Involvement of Calcineurin in Transforming Growth Factor-{beta}-mediated Regulation of Extracellular Matrix Accumulation. J. Biol. Chem. 279: 15561-15570 [Abstract] [Full Text]
Varela, D., Simon, F., Riveros, A., Jorgensen, F., Stutzin, A. (2004). NAD(P)H Oxidase-derived H2O2 Signals Chloride Channel Activation in Cell Volume Regulation and Cell Proliferation. J. Biol. Chem. 279: 13301-13304 [Abstract] [Full Text]
Liu, R.-M., Liu, Y., Forman, H. J., Olman, M., Tarpey, M. M. (2004). Glutathione regulates transforming growth factor-{beta}-stimulated collagen production in fibroblasts. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L121-L128 [Abstract] [Full Text]
Kobayashi, S., Inoue, N., Ohashi, Y., Terashima, M., Matsui, K., Mori, T., Fujita, H., Awano, K., Kobayashi, K., Azumi, H., Ejiri, J., Hirata, K.-i., Kawashima, S., Hayashi, Y., Yokozaki, H., Itoh, H., Yokoyama, M. (2003). Interaction of Oxidative Stress and Inflammatory Response in Coronary Plaque Instability: Important Role of C-Reactive Protein. Arterioscler. Thromb. Vasc. Bio. 23: 1398-1404 [Abstract] [Full Text]
Tadlock, L., Yamagiwa, Y., Hawker, J., Marienfeld, C., Patel, T. (2003). Transforming growth factor-{beta} inhibition of proteasomal activity: a potential mechanism of growth arrest. Am. J. Physiol. Cell Physiol. 285: C277-C285 [Abstract] [Full Text]
Chun, K.-H., Benbrook, D. M., Berlin, K. D., Hong, W. K., Lotan, R. (2003). The Synthetic Heteroarotinoid SHetA2 Induces Apoptosis in Squamous Carcinoma Cells through a Receptor-independent and Mitochondria-dependent Pathway. Cancer Res. 63: 3826-3832 [Abstract] [Full Text]
Sattler, M., Quinnan, L. R., Pride, Y. B., Gramlich, J. L., Chu, S. C., Even, G. C., Kraeft, S.-K., Chen, L. B., Salgia, R. (2003). 2-Methoxyestradiol alters cell motility, migration, and adhesion. Blood 102: 289-296 [Abstract] [Full Text]
Woo, C.-H., Yoo, M.-H., You, H.-J., Cho, S.-H., Mun, Y.-C., Seong, C.-M., Kim, J.-H. (2003). Transepithelial Migration of Neutrophils in Response to Leukotriene B4 Is Mediated by a Reactive Oxygen Species-Extracellular Signal-Regulated Kinase-Linked Cascade. J. Immunol. 170: 6273-6279 [Abstract] [Full Text]
Zhang, X., Liu, Y. (2003). Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1. Am. J. Physiol. Renal Physiol. 284: F1216-F1225 [Abstract] [Full Text]
Day, S. M., Duquaine, D., Mundada, L. V., Menon, R. G., Khan, B. V., Rajagopalan, S., Fay, W. P. (2003). Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis. Circulation 107: 2601-2606 [Abstract] [Full Text]
Mason, R. M., Wahab, N. A. (2003). Extracellular Matrix Metabolism in Diabetic Nephropathy. J. Am. Soc. Nephrol. 14: 1358-1373 [Abstract] [Full Text]
Shibanuma, M., Kim-Kaneyama, J.-r., Ishino, K., Sakamoto, N., Hishiki, T., Yamaguchi, K., Mori, K., Mashimo, J.-i., Nose, K. (2003). Hic-5 Communicates between Focal Adhesions and the Nucleus through Oxidant-Sensitive Nuclear Export Signal. Mol. Biol. Cell 14: 1158-1171 [Abstract] [Full Text]
Legakis, J. E., Koepke, J. I., Jedeszko, C., Barlaskar, F., Terlecky, L. J., Edwards, H. J., Walton, P. A., Terlecky, S. R. (2002). Peroxisome Senescence in Human Fibroblasts. Mol. Biol. Cell 13: 4243-4255 [Abstract] [Full Text]
Leavey, P. J., Gonzalez-Aller, C., Thurman, G., Kleinberg, M., Rinckel, L., Ambruso, D. W., Freeman, S., Kuypers, F. A., Ambruso, D. R. (2002). A 29-kDa Protein Associated with p67phox Expresses Both Peroxiredoxin and Phospholipase A2 Activity and Enhances Superoxide Anion Production by a Cell-free System of NADPH Oxidase Activity. J. Biol. Chem. 277: 45181-45187 [Abstract] [Full Text]
Cao, Q., Mak, K. M., Lieber, C. S. (2002). DLPC decreases TGF-beta 1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G1051-G1061 [Abstract] [Full Text]
Rozalski, R., Gackowski, D., Roszkowski, K., Foksinski, M., Olinski, R. (2002). The Level of 8-Hydroxyguanine, a Possible Repair Product of Oxidative DNA Damage, Is Higher in Urine of Cancer Patients than in Control Subjects. Cancer Epidemiol. Biomarkers Prev. 11: 1072-1075 [Abstract] [Full Text]
Nishino, T., Pusey, C. D., Domin, J. (2002). Elevated Akt Phosphorylation as an Indicator of Renal Tubular Epithelial Cell Stress. J. Biol. Chem. 277: 33943-33949 [Abstract] [Full Text]
Muto, A., Tashiro, S., Tsuchiya, H., Kume, A., Kanno, M., Ito, E., Yamamoto, M., Igarashi, K. (2002). Activation of Maf/AP-1 Repressor Bach2 by Oxidative Stress Promotes Apoptosis and Its Interaction with Promyelocytic Leukemia Nuclear Bodies. J. Biol. Chem. 277: 20724-20733 [Abstract] [Full Text]
Cemerski, S., Cantagrel, A., van Meerwijk, J. P. M., Romagnoli, P. (2002). Reactive Oxygen Species Differentially Affect T Cell Receptor-signaling Pathways*. J. Biol. Chem. 277: 19585-19593 [Abstract] [Full Text]
Amendt, C., Mann, A., Schirmacher, P., Blessing, M. (2002). Resistance of keratinocytes to TGF{beta}-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. J. Cell Sci. 115: 2189-2198 [Abstract] [Full Text]
Jimenez-Cervantes, C., Martinez-Esparza, M., Perez, C., Daum, N., Solano, F., Garcia-Borron, J. C. (2002). Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor. J. Cell Sci. 114: 2335-2344 [Abstract] [Full Text]
Woo, C.-H., You, H.-J., Cho, S.-H., Eom, Y.-W., Chun, J.-S., Yoo, Y.-J., Kim, J.-H. (2002). Leukotriene B4 Stimulates Rac-ERK Cascade to Generate Reactive Oxygen Species That Mediates Chemotaxis. J. Biol. Chem. 277: 8572-8578 [Abstract] [Full Text]
Devadas, S., Zaritskaya, L., Rhee, S. G., Oberley, L., Williams, M. S. (2002). Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation: Selective Regulation of Mitogen-Activated Protein Kinase Activation and Fas Ligand Expression. J. Exp. Med. 195: 59-70 [Abstract] [Full Text]
Murata, Y., Pei, Z.-M., Mori, I. C., Schroeder, J. (2001). Abscisic Acid Activation of Plasma Membrane Ca2+ Channels in Guard Cells Requires Cytosolic NAD(P)H and Is Differentially Disrupted Upstream and Downstream of Reactive Oxygen Species Production in abi1-1 and abi2-1 Protein Phosphatase 2C Mutants. Plant Cell 13: 2513-2523 [Abstract] [Full Text]
Nenoi, M., Ichimura, S., Mita, K., Yukawa, O., Cartwright, I. L. (2001). Regulation of the Catalase Gene Promoter by Sp1, CCAAT-recognizing Factors, and a WT1/Egr-related Factor in Hydrogen Peroxide-resistant HP100 Cells. Cancer Res. 61: 5885-5894 [Abstract] [Full Text]
Berk, B. C. (2001). Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms. Physiol. Rev. 81: 999-1030 [Abstract] [Full Text]
Wang, Q., Doerschuk, C. M. (2001). The p38 Mitogen-Activated Protein Kinase Mediates Cytoskeletal Remodeling in Pulmonary Microvascular Endothelial Cells Upon Intracellular Adhesion Molecule-1 Ligation. J. Immunol. 166: 6877-6884 [Abstract] [Full Text]
Karnoub, A. E., Der, C. J., Campbell, S. L. (2001). The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation. Mol. Cell. Biol. 21: 2847-2857 [Abstract] [Full Text]
HERRERA, B., ALVAREZ, ALBERTO. M., SANCHEZ, A., FERNANDEZ, M., RONCERO, C., BENITO, M., FABREGAT, I. (2001). Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor {beta} in fetal hepatocytes. FASEB J. 15: 741-751 [Abstract] [Full Text]
Hamada, J.-i., Nakata, D., Nakae, D., Kobayashi, Y., Akai, H., Konishi, Y., Okada, F., Shibata, T., Hosokawa, M., Moriuchi, T. (2001). Increased Oxidative DNA Damage in Mammary Tumor Cells by Continuous Epidermal Growth Factor Stimulation. JNCI J Natl Cancer Inst 93: 214-219 [Abstract] [Full Text]
Iseki, A., Kambe, F., Okumura, K., Hayakawa, T., Seo, H. (2000). Regulation of Thyroid Follicular Cell Function by Intracellular Redox-Active Copper. Endocrinology 141: 4373-4382 [Abstract] [Full Text]
Thannickal, V. J., Fanburg, B. L. (2000). Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L1005-L1028 [Abstract] [Full Text]
THANNICKAL, V. J., DAY, R. M., KLINZ, S. G., BASTIEN, M. C., LARIOS, J. M., FANBURG, B. L. (2000). Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-{beta}1. FASEB J. 14: 1741-1748 [Abstract] [Full Text]
Ha, H. C., Thiagalingam, A., Nelkin, B. D., Casero, R. A. Jr. (2000). Reactive Oxygen Species Are Critical for the Growth and Differentiation of Medullary Thyroid Carcinoma Cells. Clin. Cancer Res. 6: 3783-3787 [Abstract] [Full Text]
Pelaez, N. J., Braun, T. R., Paul, R. J., Meiss, R. A., Packer, C. S. (2000). H2O2 mediates Ca2+- and MLC20 phosphorylation-independent contraction in intact and permeabilized vascular muscle. Am. J. Physiol. Heart Circ. Physiol. 279: H1185-H1193 [Abstract] [Full Text]
Junn, E., Lee, K. N., Ju, H. R., Han, S. H., Im, J. Y., Kang, H. S., Lee, T. H., Bae, Y. S., Ha, K. S., Lee, Z. W., Rhee, S. G., Choi, I. (2000). Requirement of Hydrogen Peroxide Generation in TGF-{beta}1 Signal Transduction in Human Lung Fibroblast Cells: Involvement of Hydrogen Peroxide and Ca2+ in TGF-{beta}1-Induced IL-6 Expression. J. Immunol. 165: 2190-2197 [Abstract] [Full Text]
Moreno, J. J. (2000). Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth. J. Pharmacol. Exp. Ther. 294: 333-338 [Abstract] [Full Text]
Qin, S., Stadtman, E. R., Chock, P. B. (2000). Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells. Proc. Natl. Acad. Sci. USA 10.1073/pnas.130198197v1 [Abstract] [Full Text]
Mietus-Snyder, M., Gowri, M. S., Pitas, R. E. (2000). Class A Scavenger Receptor Up-regulation in Smooth Muscle Cells by Oxidized Low Density Lipoprotein. ENHANCEMENT BY CALCIUM FLUX AND CONCURRENT CYCLOOXYGENASE-2 UP-REGULATION. J. Biol. Chem. 275: 17661-17670 [Abstract] [Full Text]
Rao, G. N. (2000). Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells. LACK OF EVIDENCE FOR A ROLE OF H2O2 IN ANGIOTENSIN II-INDUCED HYPERTROPHY. J. Biol. Chem. 275: 16993-16999 [Abstract] [Full Text]
Suzukawa, K., Miura, K., Mitsushita, J., Resau, J., Hirose, K., Crystal, R., Kamata, T. (2000). Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species. J. Biol. Chem. 275: 13175-13178 [Abstract] [Full Text]
Cominacini, L., Pasini, A. F., Garbin, U., Davoli, A., Tosetti, M. L., Campagnola, M., Rigoni, A., Pastorino, A. M., Lo Cascio, V., Sawamura, T. (2000). Oxidized Low Density Lipoprotein (ox-LDL) Binding to ox-LDL Receptor-1 in Endothelial Cells Induces the Activation of NF-kappa B through an Increased Production of Intracellular Reactive Oxygen Species. J. Biol. Chem. 275: 12633-12638 [Abstract] [Full Text]
Napolitano, G., Montani, V., Giuliani, C., Di Vincenzo, S., Bucci, I., Todisco, V., Laglia, G., Coppa, A., Singer, D. S., Nakazato, M., Kohn, L. D., Colletta, G., Monaco, F. (2000). Transforming Growth Factor-{beta}1 Down-Regulation of Major Histocompatibility Complex Class I in Thyrocytes: Coordinate Regulation Of Two Separate Elements by Thyroid-Specific as Well as Ubiquitous Transcription Factors. Mol. Endocrinol. 14: 486-505 [Abstract] [Full Text]
Viedt, C., Soto, U., Krieger-Brauer, H. I., Fei, J., Elsing, C., Kubler, W., Kreuzer, J. (2000). Differential Activation of Mitogen-Activated Protein Kinases in Smooth Muscle Cells by Angiotensin II : Involvement of p22phox and Reactive Oxygen Species. Arterioscler. Thromb. Vasc. Bio. 20: 940-948 [Abstract] [Full Text]
Iyer, R., Lehnert, B. E. (2000). Factors Underlying the Cell Growth-related Bystander Responses to {{alpha}} Particles. Cancer Res. 60: 1290-1298 [Abstract] [Full Text]
De Bleser, P. J., Xu, G., Rombouts, K., Rogiers, V., Geerts, A. (1999). Glutathione Levels Discriminate between Oxidative Stress and Transforming Growth Factor-beta Signaling in Activated Rat Hepatic Stellate Cells. J. Biol. Chem. 274: 33881-33887 [Abstract] [Full Text]
Bae, G.-U., Seo, D.-W., Kwon, H.-K., Lee, H. Y., Hong, S., Lee, Z.-W., Ha, K.-S., Lee, H.-W., Han, J.-W. (1999). Hydrogen Peroxide Activates p70S6k Signaling Pathway. J. Biol. Chem. 274: 32596-32602 [Abstract] [Full Text]
Brown, M. R., Miller, F. J. Jr, Li, W.-G., Ellingson, A. N., Mozena, J. D., Chatterjee, P., Engelhardt, J. F., Zwacka, R. M., Oberley, L. W., Fang, X., Spector, A. A., Weintraub, N. L. (1999). Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells. Circ. Res. 85: 524-533 [Abstract] [Full Text]
Lee, S., Choi, H., Suh, S., Doo, I.-S., Oh, K.-Y., Jeong Choi, E., Schroeder Taylor, A. T., Low, P. S., Lee, Y. (1999). Oligogalacturonic Acid and Chitosan Reduce Stomatal Aperture by Inducing the Evolution of Reactive Oxygen Species from Guard Cells of Tomato and Commelina communis. Plant Physiol. 121: 147-152 [Abstract] [Full Text]
Halleen, J. M., Raisanen, S., Salo, J. J., Reddy, S. V., Roodman, G. D., Hentunen, T. A., Lehenkari, P. P., Kaija, H., Vihko, P., Vaananen, H. K. (1999). Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase. J. Biol. Chem. 274: 22907-22910 [Abstract] [Full Text]
Santanam, N., Auge, N., Zhou, M., Keshava, C., Parthasarathy, S. (1999). Overexpression of Human Catalase Gene Decreases Oxidized Lipid-Induced Cytotoxicity in Vascular Smooth Muscle Cells. Arterioscler. Thromb. Vasc. Bio. 19: 1912-1917 [Abstract] [Full Text]
Sattler, M., Winkler, T., Verma, S., Byrne, C. H., Shrikhande, G., Salgia, R., Griffin, J. D. (1999). Hematopoietic Growth Factors Signal Through the Formation of Reactive Oxygen Species. Blood 93: 2928-2935 [Abstract] [Full Text]
Wung, B. S., Cheng, J. J., Chao, Y. J., Hsieh, H. J., Wang, D. L. (1999). Modulation of Ras/Raf/Extracellular Signal�Regulated Kinase Pathway by Reactive Oxygen Species Is Involved in Cyclic Strain�Induced Early Growth Response-1 Gene Expression in Endothelial Cells. Circ. Res. 84: 804-812 [Abstract] [Full Text]
Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z.-X., Ferrans, V. J., Howard, B. H., Finkel, T. (1999). Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species. J. Biol. Chem. 274: 7936-7940 [Abstract] [Full Text]
Cheng, T.H., Shih, N.L., Chen, S.Y., Wang, D.L., Chen, J.J. (1999). Reactive oxygen species modulate endothelin-I-induced c-fos gene expression in cardiomyocytes. Cardiovasc Res 41: 654-662 [Abstract] [Full Text]
Rao, G. N., Katki, K. A., Madamanchi, N. R., Wu, Y., Birrer, M. J. (1999). JunB Forms the Majority of the AP-1 Complex and Is a Target for Redox Regulation by Receptor Tyrosine Kinase and G Protein-coupled Receptor Agonists in Smooth Muscle Cells. J. Biol. Chem. 274: 6003-6010 [Abstract] [Full Text]
Marumo, T., Schini-Kerth, V. B., Brandes, R. P., Busse, R. (1998). Glucocorticoids Inhibit Superoxide Anion Production and p22 Phox mRNA Expression in Human Aortic Smooth Muscle Cells. Hypertension 32: 1083-1088 [Abstract] [Full Text]
Filep, J. G., Beauchamp, M., Baron, C., Paquette, Y. (1998). Peroxynitrite Mediates IL-8 Gene Expression and Production in Lipopolysaccharide-Stimulated Human Whole Blood. J. Immunol. 161: 5656-5662 [Abstract] [Full Text]
Grande, J P (1998). Mechanisms of progression of renal damage in lupus nephritis:Pathogenesis of renal scarring. Lupus 7: 604-610 [Abstract]
Thannickal, V. J., Aldweib, K. D.�L., Fanburg, B. L. (1998). Tyrosine Phosphorylation Regulates H2O2 Production in Lung Fibroblasts Stimulated by Transforming Growth Factor beta 1. J. Biol. Chem. 273: 23611-23615 [Abstract] [Full Text]
Mietus-Snyder, M., Glass, C. K., Pitas, R. E. (1998). Transcriptional Activation of Scavenger Receptor Expression in Human Smooth Muscle Cells Requires AP-1/c-Jun and C/EBP� : Both AP-1 Binding and JNK Activation Are Induced by Phorbol Esters and Oxidative Stress. Arterioscler. Thromb. Vasc. Bio. 18: 1440-1449 [Abstract] [Full Text]
Zafari, A. M., Ushio-Fukai, M., Akers, M., Yin, Q., Shah, A., Harrison, D. G., Taylor, W. R., Griendling, K. K. (1998). Role of NADH/NADPH Oxidase�Derived H2O2 in Angiotensin II�Induced Vascular Hypertrophy. Hypertension 32: 488-495 [Abstract] [Full Text]
Liao, J. K. (1998). Endothelium and acute coronary syndromes. Clin. Chem. 44: 1799-1808 [Abstract] [Full Text]
Factor, V. M., Kiss, A., Woitach, J. T., Wirth, P. J., Thorgeirsson, S. S. (1998). Disruption of Redox Homeostasis in the Transforming Growth Factor-alpha /c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis. J. Biol. Chem. 273: 15846-15853 [Abstract] [Full Text]
Ushio-Fukai, M., Alexander, R. W., Akers, M., Griendling, K. K. (1998). p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II. ROLE IN VASCULAR SMOOTH MUSCLE CELL HYPERTROPHY. J. Biol. Chem. 273: 15022-15029 [Abstract] [Full Text]
Suhara, T., Fukuo, K., Sugimoto, T., Morimoto, S., Nakahashi, T., Hata, S., Shimizu, M., Ogihara, T. (1998). Hydrogen Peroxide Induces Up-Regulation of Fas in Human Endothelial Cells. J. Immunol. 160: 4042-4047 [Abstract] [Full Text]
Kang, S. W., Chae, H. Z., Seo, M. S., Kim, K., Baines, I. C., Rhee, S. G. (1998). Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-alpha. J. Biol. Chem. 273: 6297-6302 [Abstract] [Full Text]
Kang, S. W., Baines, I. C., Rhee, S. G. (1998). Characterization of a Mammalian Peroxiredoxin That Contains One Conserved Cysteine. J. Biol. Chem. 273: 6303-6311 [Abstract] [Full Text]
Cheng, J.-J., Wung, B.-S., Chao, Y.-J., Wang, D. L. (1998). Cyclic Strain-Induced Reactive Oxygen Species Involved in ICAM-1 Gene Induction in Endothelial Cells. Hypertension 31: 125-130 [Abstract] [Full Text]
Pombo, C. M., Tsujita, T., Kyriakis, J. M., Bonventre, J. V., Force, T. (1997). Activation of the Ste20-like Oxidant Stress Response Kinase-1 during the Initial Stages of Chemical Anoxia-induced Necrotic Cell Death. REQUIREMENT FOR DUAL INPUTS OF OXIDANT STRESS AND INCREASED CYTOSOLIC [Ca2+]. J. Biol. Chem. 272: 29372-29379 [Abstract] [Full Text]
Mietus-Snyder, M., Friera, A., Glass, C. K., Pitas, R. E. (1997). Regulation of Scavenger Receptor Expression in Smooth Muscle Cells by Protein Kinase C: A Role for Oxidative Stress. Arterioscler. Thromb. Vasc. Bio. 17: 969-978 [Abstract] [Full Text]
Pantopoulos, K., Mueller, S., Atzberger, A., Ansorge, W., Stremmel, W., Hentze, M. W. (1997). Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress. J. Biol. Chem. 272: 9802-9808 [Abstract] [Full Text]
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., Goldschmidt-Clermont, P. J. (1997). Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts. Science 275: 1649-1652 [Abstract] [Full Text]
Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I. C., Tekle, E., Chock, P. B., Rhee, S. G. (1997). Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide. ROLE IN EGF RECEPTOR-MEDIATED TYROSINE PHOSPHORYLATION. J. Biol. Chem. 272: 217-221 [Abstract] [Full Text]
Kamata, H., Tanaka, C., Yagisawa, H., Matsuda, S., Gotoh, Y., Nishida, E., Hirata, H. (1996). Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells. N-ACETYLCYSTEINE UNCOUPLES THE SIGNAL TRANSDUCTION FROM Ras TO THE MITOGEN-ACTIVATED PROTEIN KINASE CASCADE. J. Biol. Chem. 271: 33018-33025 [Abstract] [Full Text]
Speir, E., Shibutani, T., Yu, Z.-X., Ferrans, V., Epstein, S. E. (1996). Role of Reactive Oxygen Intermediates in Cytomegalovirus Gene Expression and in the Response of Human Smooth Muscle Cells to Viral Infection. Circ. Res. 79: 1143-1152 [Abstract] [Full Text]
Ushio-Fukai, M., Zafari, A. M., Fukui, T., Ishizaka, N., Griendling, K. K. (1996). p22phox Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells. J. Biol. Chem. 271: 23317-23321 [Abstract] [Full Text]
S�nchez, A.�n., Alvarez, A. M., Benito, M., Fabregat, I. (1996). Apoptosis Induced by Transforming Growth Factor-beta in Fetal Hepatocyte Primary Cultures. J. Biol. Chem. 271: 7416-7422 [Abstract] [Full Text]