J. Cell Biol.
© The Rockefeller University Press
0021-9525/97/03/1007/15 $2.00
Volume 136, Number 5, March 10, 1997 1007-1021

Microtubule-mediated Transport of Incoming Herpes Simplex Virus 1 Capsids to the Nucleus

Beate Sodeik, Melanie W. Ebersold, and Ari Helenius

Yale University School of Medicine, Department of Cell Biology, New Haven, Connecticut 06520-8002

Herpes simplex virus 1 fuses with the plasma membrane of a host cell, and the incoming capsids are efficiently and rapidly transported across the cytosol to the nuclear pore complexes, where the viral DNA genomes are released into the nucleoplasm. Using biochemical assays, immunofluorescence, and immunoelectron microscopy in the presence and absence of microtubule depolymerizing agents, it was shown that the cytosolic capsid transport in Vero cells was mediated by microtubules. Antibody labeling revealed the attachment of dynein, a minus end-directed, microtubule-dependent motor, to the viral capsids. We propose that the incoming capsids bind to microtubules and use dynein to propel them from the cell periphery to the nucleus.

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• Mossman, K. L., Macgregor, P. F., Rozmus, J. J., Goryachev, A. B., Edwards, A. M., Smiley, J. R. (2001). Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response. J. Virol. 75: 750-758 [Abstract] [Full Text]  
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• Kim, S.-W., Ihn, K.-S., Han, S.-H., Seong, S.-Y., Kim, I.-S., Choi, M.-S. (2001). Microtubule- and Dynein-Mediated Movement of Orientia tsutsugamushi to the Microtubule Organizing Center. Infect. Immun. 69: 494-500 [Abstract] [Full Text]  
• Sinzger, C., Kahl, M., Laib, K., Klingel, K., Rieger, P., Plachter, B., Jahn, G. (2000). Tropism of human cytomegalovirus for endothelial cells is determined by a post-entry step dependent on efficient translocation to the nucleus. J. Gen. Virol. 81: 3021-3035 [Abstract] [Full Text]  

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