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J. Cell Biol., Volume 140, Number 3, February 9, 1998 685-698

Thy-1 Is a Component Common to Multiple Populations of Synaptic Vesicles

Chung-Jiuan Jeng,* Steven A. McCarroll,Dagger Thomas F. J. Martin,§ Erik Floor,par James Adams,* David Krantz,Dagger Stefan Butz, Robert Edwards,Dagger and Erik S. Schweitzer*

* Department of Neurobiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095-1763; Dagger  Departments of Neurology and Physiology, and Graduate Program in Neuroscience and Cell Biology, UCSF School of Medicine, San Francisco, California 94143-0435; § Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706-1569; par  Department of Biochemistry, Cell & Molecular Biology, University of Kansas, Lawrence, Kansas 66045-2106; and  Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235

Thy-1, a glycosylphosphatidylinositol-linked integral membrane protein of the immunoglobulin superfamily, is a component of both large dense-core and small clear vesicles in PC12 cells. A majority of this protein, formerly recognized only on the plasma membrane of neurons, is localized to regulated secretory vesicles. Thy-1 is also present in synaptic vesicles in rat central nervous system. Experiments on permeabilized PC12 cells demonstrate that antibodies against Thy-1 inhibit the regulated release of neurotransmitter; this inhibition appears to be independent of any effect on the Ca2+ channel. These findings suggest Thy-1 is an integral component of many types of regulated secretory vesicles, and plays an important role in the regulated vesicular release of neurotransmitter at the synapse.


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