Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

doi:10.1083/jcb.143.2.457

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J. Cell Biol., Volume 143, Number 2, October 19, 1998 457-467

Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

David S. Park,^* Erick J. Morris, Jaya Padmanabhan,^* Michael L. Shelanski,^* Herbert M. Geller, and Lloyd A. Greene^*

^* Department of Pathology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854

Previous reports have indicated that DNA-damaging treatments including certain anticancer therapeutics cause death of postmitoticnerve cells both in vitro and in vivo. Accordingly, it has becomeimportant to understand the signaling events that control thisprocess. We recently hypothesized that certain cell cycle moleculesmay play an important role in neuronal death signaling evokedby DNA damage. Consequently, we examined whether cyclin-dependentkinase inhibitors (CKIs) and dominant-negative (DN) cyclin-dependentkinases (CDK) protect sympathetic and cortical neurons againstDNA-damaging conditions. We show that Sindbis virus-induced expressionof CKIs p16^ink4, p21^waf/cip1, and p27^kip1, as well as DN-Cdk4 and 6, but not DN-Cdk2 or 3, protect sympatheticneurons against UV irradiation- and AraC-induced death. We alsodemonstrate that the CKIs p16 and p27 as well as DN-Cdk4 and 6but not DN-Cdk2 or 3 protect cortical neurons from the DNA damagingagent camptothecin. Finally, in consonance with our hypothesisand these results, cyclin D1-associated kinase activity is rapidlyand highly elevated in cortical neurons upon camptothecin treatment.These results suggest that postmitotic neurons may utilize Cdk4and 6, signals that normally control proliferation, to mediatedeath signaling resulting from DNA-damaging conditions.

Key words: apoptosis; CDK; neuronal; cell cycle; DNA damage

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