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J. Cell Biol.,
Volume 144, Number 4, February 22, 1999 777-788
* Department of Immunology, § Department of Cell Biology, and Lymphocytes accumulate within the extracellular matrix (ECM) of tumor, wound, or inflammatory tissues. These tissues are largely comprised
of polymerized adhesion proteins such as fibrin and fibronectin or their fragments. Nonactivated lymphoid
cells attach preferentially to polymerized ECM proteins yet are unable to attach to monomeric forms or
fragments of these proteins without previous activation.
This adhesion event depends on the appropriate spacing of integrin adhesion sites. Adhesion of nonactivated
lymphoid cells to polymeric ECM components results
in activation of the antigen receptor-associated Syk kinase that accumulates in adhesion-promoting podosomes. In fact, activation of Syk by antigen or agonists, as well as expression of an activated Syk mutant in lymphoid cells, facilitates their adhesion to monomeric
ECM proteins or their fragments. These results reveal a
cooperative interaction between signals emanating
from integrins and antigen receptors that can serve to
regulate stable lymphoid cell adhesion and retention within a remodeling ECM.
Department of Vascular Biology, The Scripps Research
Institute, La Jolla, California 92037; and Department of Medicinal Chemistry and Pharmacology, Purdue University,
West Lafayette, Indiana 47907
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