A Novel Muscle-specific {beta}1 Integrin Binding Protein (MIBP) that Modulates Myogenic Differentiation

doi:10.1083/jcb.147.7.1391

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© The Rockefeller University Press, 0021-9525/1999/12/1391/ $5.00
The Journal of Cell Biology, Volume 147, Number 7, December 27, 1999 1391-1398

Brief Report

A Novel Muscle-specific ß1 Integrin Binding Protein (MIBP) that Modulates Myogenic Differentiation

Ji Li^a, Richard Mayne^a, and Chuanyue Wu^a
^a Department of Cell Biology and The Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019

Correspondence to: Chuanyue Wu, VH 217, Department of Cell Biology, University of Alabama at Birmingham, 1670 University Blvd., Birmingham, AL 35294-0019. Tel:(205) 975-2253 Fax:(205) 934-7029 E-mail:cwu{at}cellbio.bhs.uab.edu.

Myogenesis is regulated by cell adhesion receptors, includingintegrins of the ß1 family. We report the identificationof a novel muscle-specific ß1 integrin binding protein(MIBP). MIBP binds to the membrane-proximal cytoplasmic regionshared by ß1A and ß1D integrins, and the bindingoccurs in vivo as well as in vitro. Furthermore, we show thatMIBP is abundantly expressed by C2C12 myogenic cells beforefusion, and the expression of MIBP is dramatically downregulatedduring subsequent differentiation. Finally, we show that overexpressionof MIBP in C2C12 cells resulted in a suppression of fusion andterminal differentiation, suggesting that MIBP may play a keyrole in controlling the progression of muscle differentiation.

Key Words: integrin binding protein, muscle, myogenic differentiation,signal transduction, myogenin

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