Brief Report

Caspase Recruitment Domain (CARD)-dependent Cytoplasmic Filaments Mediate bcl10-induced NF-B Activation

Correspondence to: Pasquale Vito, Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH-4005, Basel, Switzerland. Tel:061-605-1349 Fax:061-605-1364 E-mail:Vito{at}bii.ch.

Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-B. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-B activation. We also show that cytoskeleton elements regulate bcl10 signaling.

Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling.

Key Words: bcl10, filaments, mucosa-associated lymphoid tissue, NF-B, scaffold

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