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Original Article |
Correspondence to: Peter Sonderegger, Institute of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland. Tel:41-1-635-55-41 Fax:41-1-635-68-31 E-mail:pson{at}bioc.unizh.ch.
An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti–axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth.
Key Words: axon guidance, growth cone, neuronal cell adhesion molecules, immunoglobulin superfamily, signal transduction
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