JIL-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (MSL) Dosage Compensation Complex

doi:10.1083/jcb.149.5.1005

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© The Rockefeller University Press, 0021-9525/2000/5/1005/ $5.00
The Journal of Cell Biology, Volume 149, Number 5, May 29, 2000 1005-1010

Brief Report

JIL-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (MSL) Dosage Compensation Complex

Ye Jin^a, Yanming Wang^a, Jørgen Johansen^a, and Kristen M. Johansen^a
^a Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011

Correspondence to: Kristen M. Johansen, Department of Zoology and Genetics, 3154 Molecular Biology Building, Iowa State University, Ames, IA 50011. Tel:(515) 294-7959 Fax:(515) 294-0345 E-mail:kristen{at}iastate.edu.

JIL-1 is a novel chromosomal kinase that is upregulated almosttwofold on the male X chromosome in Drosophila. Here we demonstratethat JIL-1 colocalizes and physically interacts with male specificlethal (MSL) dosage compensation complex proteins. Furthermore,ectopic expression of the MSL complex directed by MSL2 in femalescauses a concomitant upregulation of JIL-1 to the female X thatis abolished in msl mutants unable to assemble the complex.Thus, these results strongly indicate JIL-1 associates withthe MSL complex and further suggests JIL-1 functions in signaltransduction pathways regulating chromatin structure.

Key Words: protein kinase, dosage compensation, Drosophila, chromatin,MSL complex

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