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The Journal of Cell Biology, Vol 15, 509-523, Copyright © 1962 by Rockefeller University Press

ARTICLE

THE EFFECT OF INSULIN, ALLOXAN DIABETES, AND ANOXIA ON THE ULTRASTRUCTURE OF THE RAT HEART

David N. Orth 1 and Howard E. Morgan 1

1 From the Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee.

Dr. Orth's present address is Department of Medicine, The Johns Hopkins Hospital, Baltimore. Dr. Morgan is an Investigator, Howard Hughes Medical Institute

Hearts from normal and alloxan diabetic rats were perfused in vitro with a bicarbonate-buffered medium containing glucose. Transport of glucose through the cell membrane was stimulated with insulin or by induction of anaerobiosis. The organs were rapidly fixed and examined by electron microscopy. Transport stimulation was not associated with any increase in the number of sarcolemmal invaginations or subsarcolemmal cytoplasmic vesicles. It was concluded that glucose transport and the effects of insulin or anoxia do not involve pinocytosis. The relationship of pinocytosis to glucose transport is discussed. The appearance of numerous lipid inclusions at the Z line level of the sarcomeres in the diabetic and anoxic myocardia is described.

Submitted on June 18, 1962


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