Importin {beta}-mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation

doi:10.1083/jcb.152.6.1307

Published online 19 March 2001. doi:10.1083/jcb.152.6.1307

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© The Rockefeller University Press, 0021-9525/2001/3/1307/ $5.00
The Journal of Cell Biology, Volume 152, Number 6, March 19, 2001 1307-1312

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Importin ß–mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation

John F. Reilly^a and Pamela A. Maher^a
^a Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037

Correspondence to: Pamela A. Maher, Dept. of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., CAL-3, La Jolla, CA 92037. Tel:(858) 784-7712 Fax:(858) 784-7675 E-mail:pmaher{at}scripps.edu.

Although growth factor receptors are generally thought to carryout their role in signal transduction at the cell surface, manyof these transmembrane proteins translocate to the nucleus afterligand stimulation. Here, we show that the nuclear translocationof fibroblast growth factor receptor (FGFR)1 occurs via a mechanismdistinct from classical nuclear import but dependent on importinß, a component of multiple nuclear import pathways.Furthermore, we show that nuclear FGFR1 induces c-Jun and isinvolved in the regulation of cell proliferation. These dataare the first description of a nuclear import pathway for transmembranegrowth factor receptors and elucidate a novel signal transductionpathway from the cell surface to the nucleus.

Key Words: FGF receptor, importin ß, nuclear transport, c Jun,cyclin D1

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