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Published online 7 May 2001. doi:10.1083/jcb.153.4.677
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© The Rockefeller University Press, 0021-9525/2001/5/677/ $5.00
The Journal of Cell Biology, Volume 153, Number 4, May 14, 2001 677-686

Original Article

Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels

Jacqueline Fischer-Lougheeda, Jian-Hui Liua,c, Estelle Espinosa, David Mordasinia, Charles R. Baderc, Dominique Belinb, and Laurent Bernheima
a Département de Physiologie et, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland
b Département de Pathologie, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland
c Division de Recherche Clinique Neuro-Musculaire, Département des Neurosciences Cliniques et Dermatologie, Hôpital Cantonal Universitaire, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland

Correspondence to: Laurent Bernheim, Département de Physiologie, Centre Médical Universitaire, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland. Tel:(41) 22 702 53 92

Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through {alpha}1H T channels.

Key Words: potassium current, membrane potential, myoblast fusion, muscle, antisense


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