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School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, United Kingdom

Address correspondence to Laura Machesky, Division of Molecular and Cellular Biology, University of Birmingham, School of Biosciences, Birmingham B15 2TT, UK. Tel.: 44-121-414-2504. Fax: 44-121-414-5925. E-mail: l.m.machesky{at}bham.ac.uk

Abstract
Recently, two new ligands of the Arp2/3 complex have been described that may shed light on the way cells organize complex networks of actin in response to signals. Abp1p, a yeast protein involved in endocytosis, and cortactin, a mammalian src substrate, both enhance the ability of the Arp2/3 complex to assemble branched actin filament networks.

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