Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text PDF (Full Text) Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hoyt, M. A. Search for Related Content PubMed PubMed Citation Articles by Hoyt, M. A. Related Collections Related Article Social Bookmarking                      What's this?

Department of Biology, The Johns Hopkins University, Baltimore, MD 21218

Address correspondence to M. Andrew Hoyt, Dept. of Biology, Mudd Hall, Rm. 36, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218. Tel.: (410) 516-7299. Fax: (410) 516- 5213. E-mail: hoyt{at}jhu.edu

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

The spindle assembly checkpoint gets a complex

Alan W. Dove
J. Cell Biol. 2001 154: 902-903. [Full Text] [PDF]

This article has been cited by other articles:

• Xiong, B., Li, S., Ai, J.-S., Yin, S., OuYang, Y.-C., Sun, S.-C., Chen, D.-Y., Sun, Q.-Y. (2008). BRCA1 Is Required for Meiotic Spindle Assembly and Spindle Assembly Checkpoint Activation in Mouse Oocytes. Biol. Reprod. 79: 718-726 [Abstract] [Full Text]  
• Zhang, D., Yin, S., Jiang, M.-X., Ma, W., Hou, Y., Liang, C.-G., Yu, L.-Z., Wang, W.-H., Sun, Q.-Y. (2007). Cytoplasmic dynein participates in meiotic checkpoint inactivation in mouse oocytes by transporting cytoplasmic mitotic arrest-deficient (Mad) proteins from kinetochores to spindle poles. Reproduction 133: 685-695 [Abstract] [Full Text]  
• Oikawa, T., Okuda, M., Ma, Z., Goorha, R., Tsujimoto, H., Inokuma, H., Fukasawa, K. (2005). Transcriptional Control of BubR1 by p53 and Suppression of Centrosome Amplification by BubR1. Mol. Cell. Biol. 25: 4046-4061 [Abstract] [Full Text]  
• Zhang, D., Li, M., Ma, W., Hou, Y., Li, Y.-H., Li, S.-W., Sun, Q.-Y., Wang, W.-H. (2005). Localization of Mitotic Arrest Deficient 1 (MAD1) in Mouse Oocytes During the First Meiosis and Its Functions as a Spindle Checkpoint Protein. Biol. Reprod. 72: 58-68 [Abstract] [Full Text]  
• Dey, P (2004). Aneuploidy and malignancy: an unsolved equation. J. Clin. Pathol. 57: 1245-1249 [Abstract] [Full Text]  
• Zhang, D., Ma, W., Li, Y.-H., Hou, Y., Li, S.-W., Meng, X.-Q., Sun, X.-F., Sun, Q.-Y., Wang, W.-H. (2004). Intra-oocyte Localization of MAD2 and Its Relationship with Kinetochores, Microtubules, and Chromosomes in Rat Oocytes During Meiosis. Biol. Reprod. 71: 740-748 [Abstract] [Full Text]  
• Einarson, M. B., Cukierman, E., Compton, D. A., Golemis, E. A. (2004). Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis. Mol. Cell. Biol. 24: 3957-3971 [Abstract] [Full Text]  
• Wang, Q., Liu, T., Fang, Y., Xie, S., Huang, X., Mahmood, R., Ramaswamy, G., Sakamoto, K. M., Darzynkiewicz, Z., Xu, M., Dai, W. (2004). BUBR1 deficiency results in abnormal megakaryopoiesis. Blood 103: 1278-1285 [Abstract] [Full Text]  
• Dai, W., Wang, Q., Liu, T., Swamy, M., Fang, Y., Xie, S., Mahmood, R., Yang, Y.-M., Xu, M., Rao, C. V. (2004). Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency. Cancer Res. 64: 440-445 [Abstract] [Full Text]  
• Yin, M.-J., Shao, L., Voehringer, D., Smeal, T., Jallal, B. (2003). The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis. J. Biol. Chem. 278: 52454-52460 [Abstract] [Full Text]  
• Chiroli, E., Fraschini, R., Beretta, A., Tonelli, M., Lucchini, G., Piatti, S. (2003). Budding yeast PAK kinases regulate mitotic exit by two different mechanisms. J. Cell Biol. 160: 857-874 [Abstract] [Full Text]  
• Schuyler, S. C., Liu, J. Y., Pellman, D. (2003). The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. J. Cell Biol. 160: 517-528 [Abstract] [Full Text]  
• Babu, J. R., Jeganathan, K. B., Baker, D. J., Wu, X., Kang-Decker, N., van Deursen, J. M. (2003). Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J. Cell Biol. 160: 341-353 [Abstract] [Full Text]  
• Iouk, T., Kerscher, O., Scott, R. J., Basrai, M. A., Wozniak, R. W. (2002). The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J. Cell Biol. 159: 807-819 [Abstract] [Full Text]  
• Kitazono, A. A., Kron, S. J. (2002). An Essential Function of Yeast Cyclin-dependent Kinase Cdc28 Maintains Chromosome Stability. J. Biol. Chem. 277: 48627-48634 [Abstract] [Full Text]  
• Warren, C. D., Brady, D. M., Johnston, R. C., Hanna, J. S., Hardwick, K. G., Spencer, F. A. (2002). Distinct Chromosome Segregation Roles for Spindle Checkpoint Proteins. Mol. Biol. Cell 13: 3029-3041 [Abstract] [Full Text]  
• Garber, P. M., Rine, J. (2002). Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae. Genetics 161: 521-534 [Abstract] [Full Text]  
• Canman, J. C., Sharma, N., Straight, A., Shannon, K. B., Fang, G., Salmon, E. D. (2002). Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins. J. Cell Sci. 115: 3787-3795 [Abstract] [Full Text]  
• Howell, B.J., McEwen, B.F., Canman, J.C., Hoffman, D.B., Farrar, E.M., Rieder, C.L., Salmon, E.D. (2001). Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J. Cell Biol. 155: 1159-1172 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents