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Department of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway

Address correspondence to Harald Stenmark, Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway. Tel.: (47) 2293-4951. Fax: (47) 2250-8692. E-mail: stenmark{at}ulrik.uio.no

Phosphoinositide 3 kinases (PI3Ks)^* are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P₃) and phosphatidylinositol 3-phosphate (PI[3]P), accumulate transiently at different stages. Phagosomes containing Mycobacterium tuberculosis do not acquire the PI(3)P-binding protein EEA1, which is required for phagosome maturation. This suggests a possible mechanism of how this microorganism evades degradation in phagolysosomes.

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