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Published 24 December 2001. doi:10.1083/jcb.200110160
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© The Rockefeller University Press, 0021-9525/2001/12/1099 $5.00
The Journal of Cell Biology, Volume 155, Number 7, December 24, 2001 1099-1102

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 Traffic through the Golgi apparatus

Hugh R.B. Pelham

Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, UK

Address correspondence to Hugh Pelham, Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, UK. Tel. 44-1223-402290. Fax: 44-1223-412142. E-mail: hp{at}mrc-lmb.cam.ac.uk

The role of vesicles in cargo transport through the Golgi apparatus has been controversial. Large forms of cargo such as protein aggregates are thought to progress through the Golgi stack by a process of cisternal maturation, balanced by a return flow of Golgi resident proteins in COPI-coated vesicles. However, whether this is the primary role of vesicles, or whether they also serve to transport small cargo molecules in a forward direction has been debated. Two papers (Martínez-Menárguez et al., 2001; Mironov et al., 2001, this issue) use sophisticated light and electron microscopy to provide evidence that the vesicular stomatitis virus membrane glycoprotein (VSV G)* is largely excluded from vesicles in vivo, and does not move between cisternae, whereas resident Golgi enzymes freely enter vesicles as predicted by the cisternal maturation model. Both papers conclude that vesicles are likely to play only a minor role in the anterograde transport of cargo through the Golgi apparatus in mammalian tissue culture cells.


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