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Published 18 March 2002. doi:10.1083/jcb.200202116
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© The Rockefeller University Press, 0021-9525/2002/3/947 $5.00
The Journal of Cell Biology, Volume 156, Number 6, March 18, 2002 947-949

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 Keratinocyte junctions and the epidermal barrier : how to make a skin-tight dress



Gianfranco Bazzoni1 and Elisabetta Dejana1,2

1 Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
2 FIRC Institute of Molecular Oncology, 20139 Milan, Italy

Address correspondence to Dr. Elisabetta Dejana, FIRC Institute of Molecular Oncology, Via Serio 21, 20139 Milan, Italy. Tel.: 39-02-574-303-235. Fax: 39-02-574-303-244. E-mail: dejana{at}ifom-firc.it

Although intercellular junctions are known to be the major regulators of permeability of simple epithelia, they had not been thought to be important in regulating the permeability of stratified mammalian epithelia. Furuse et al. (2002)(this issue) demonstrate that functional tight junctions may indeed be a necessary part of the permeability barrier of the skin.


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