Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

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Published 24 June 2002. doi:10.1083/jcb.200203073

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© The Rockefeller University Press, 0021-9525/2002/6/1279 $5.00
The Journal of Cell Biology, Volume 157, Number 7, June 24, 2002 1279-1290

Article

Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

Shaohua Li¹, David Harrison¹, Salvatore Carbonetto²^,3, Reinhard Fässler⁴, Neil Smyth⁵, David Edgar⁶ and Peter D. Yurchenco¹

¹ Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ), Robert Wood Johnson Medical School, Piscataway, NJ 08854
² Department of Neurology and Neurosurgery, McGill University
³ Center for Neuroscience Research, Montréal General Hospital Research Institute, Montréal, Québec H3G 1A4, Canada
⁴ Max-Planck Institute for Biochemistry, D-8285 Martinsried, Germany
⁵ Institute for Biochemistry II, Medical Faculty, University of Cologne, D-50924 Cologne, Germany
⁶ Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3G3E, UK

Address correspondence to Peter D. Yurchenco, Dept. of Pathology and Laboratory Medicine, UMDNJ, Robert Wood Johnson Medical School, 675 Hoes Ln., Piscataway, NJ 08854. Tel.: (732) 235-5166. Fax: (732) 235-4825. E-mail: yurchenc{at}umdnj.edu

Laminin-1 is essential for early embryonic basement membraneassembly and differentiation. Several steps can be distinguished,i.e., the expression of laminin and companion matrix components,their accumulation on the cell surface and assembly into basementmembrane between endoderm and inner cell mass, and the ensuingdifferentiation of epiblast. In this study, we used differentiatingembryoid bodies derived from mouse embryonic stem cells nullfor ${gamma}$ 1-laminin, ß1-integrin and ${alpha}$ /ß-dystroglycanto dissect the contributions of laminin domains and interactingreceptors to this process. We found that (a) laminin enablesß1-integrin–null embryoid bodies to assemblebasement membrane and achieve epiblast with ß1-integrinenabling expression of the laminin ${alpha}$ 1 subunit; (b) basement membraneassembly and differentiation require laminin polymerizationin conjunction with cell anchorage, the latter critically dependentupon a heparin-binding locus within LG module-4; (c) dystroglycanis not uniquely required for basement membrane assembly or initialdifferentiation; (d) dystroglycan and integrin cooperate tosustain survival of the epiblast and regulate laminin expression;and (e) laminin, acting via ß1-integrin through LG1–3and requiring polymerization, can regulate dystroglycan expression.

Key Words: basement membrane; gastrulation; integrin; dystroglycan; apoptosis

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