Published 8 July 2002. doi:10.1083/jcb.200202100
© The Rockefeller University Press,
0021-9525/2002/7/17 $5.00
The Journal of Cell Biology, Volume 158, Number 1, July 8, 2002 17-21
Tiny dancers
:
the integrin–growth factor nexus in angiogenic signaling
Susan S. Smyth1 and
Cam Patterson1,2
1 Department of Medicine (Cardiology) and The Carolina Cardiovascular Biology Center, The University of North Carolina, Chapel Hill, NC 27599
2 Department of Cell and Developmental Biology and Department of Pharmacology, The University of North Carolina, Chapel Hill, NC 27599
Address correspondence to Cam Patterson, 5109 Neuroscience Research Bldg., CB#7126, The Carolina Cardiovascular Biology Center, The University of North Carolina, Chapel Hill, NC 27599-7126. Tel.: (919) 843-6477. Fax: (919) 843-4585. E-mail: cpatters{at}med.unc.edu
Abstract
A vital step in growth factor–driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix. The molecular mechanisms that partner growth factors and integrins are being elucidated, revealing an intricate interaction of surface receptors and their signaling pathways.
Key Words: angiogenesis; growth factors; growth factor receptors; integrins; signal transduction pathways
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