Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text PDF (Full Text) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Umezu-Goto, M. Articles by Arai, H. Search for Related Content PubMed PubMed Citation Articles by Umezu-Goto, M. Articles by Arai, H. Social Bookmarking                      What's this?

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
² Biomolecular Characterization Division, The Institute of Physical and Chemical Research, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan
³ Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Toshima-ku, Tokyo 170-8455, Japan
⁴ Department of Molecular Therapeutics, MD Anderson Cancer Center, Houston, TX 77030

Address correspondence to Junken Aoki, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 Japan. Tel.: 81-3-5841-4723. Fax: 81-3-3818-3173. E-mail: jaoki{at}mol.f.u-tokyo.ac.jp

Autotaxin (ATX) is a tumor cell motility–stimulating factor, originally isolated from melanoma cell supernatants. ATX had been proposed to mediate its effects through 5'-nucleotide pyrophosphatase and phosphodiesterase activities. However, the ATX substrate mediating the increase in cellular motility remains to be identified. Here, we demonstrated that lysophospholipase D (lysoPLD) purified from fetal bovine serum, which catalyzes the production of the bioactive phospholipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine (LPC), is identical to ATX. The Km value of ATX for LPC was 25-fold lower than that for the synthetic nucleoside substrate, p-nitrophenyl-tri-monophosphate. LPA mediates multiple biological functions including cytoskeletal reorganization, chemotaxis, and cell growth through activation of specific G protein–coupled receptors. Recombinant ATX, particularly in the presence of LPC, dramatically increased chemotaxis and proliferation of multiple different cell lines. Moreover, we demonstrate that several cancer cell lines release significant amounts of LPC, a substrate for ATX, into the culture medium. The demonstration that ATX and lysoPLD are identical suggests that autocrine or paracrine production of LPA contributes to tumor cell motility, survival, and proliferation. It also provides potential novel targets for therapy of pathophysiological states including cancer.

Key Words: lysoPLD; EDG receptor; lysophosphatidylcholine; chemotaxis; cell proliferation

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Hosogaya, S., Yatomi, Y., Nakamura, K., Ohkawa, R., Okubo, S., Yokota, H., Ohta, M., Yamazaki, H., Koike, T., Ozaki, Y. (2008). Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity. Ann Clin Biochem 45: 364-368 [Abstract] [Full Text]  
• Giganti, A., Rodriguez, M., Fould, B., Moulharat, N., Coge, F., Chomarat, P., Galizzi, J.-P., Valet, P., Saulnier-Blache, J.-S., Boutin, J. A., Ferry, G. (2008). Murine and Human Autotaxin {alpha}, {beta}, and {gamma} Isoforms: GENE ORGANIZATION, TISSUE DISTRIBUTION, AND BIOCHEMICAL CHARACTERIZATION. J. Biol. Chem. 283: 7776-7789 [Abstract] [Full Text]  
• Ptaszynska, M. M., Pendrak, M. L., Bandle, R. W., Stracke, M. L., Roberts, D. D. (2008). Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells. Mol Cancer Res 6: 352-363 [Abstract] [Full Text]  
• Billon-Denis, E., Tanfin, Z., Robin, P. (2008). Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin. J. Lipid Res. 49: 295-307 [Abstract] [Full Text]  
• Zhao, C., Fernandes, M. J., Prestwich, G. D., Turgeon, M., Di Battista, J., Clair, T., Poubelle, P. E., Bourgoin, S. G. (2008). Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis?. Mol. Pharmacol. 73: 587-600 [Abstract] [Full Text]  
• Han, M. S., Park, S. Y., Shinzawa, K., Kim, S., Chung, K. W., Lee, J.-H., Kwon, C. H., Lee, K.-W., Lee, J.-H., Park, C. K., Chung, W. J., Hwang, J. S., Yan, J.-J., Song, D.-K., Tsujimoto, Y., Lee, M.-S. (2008). Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J. Lipid Res. 49: 84-97 [Abstract] [Full Text]  
• Ganguly, K., Stoeger, T., Wesselkamper, S. C., Reinhard, C., Sartor, M. A., Medvedovic, M., Tomlinson, C. R., Bolle, I., Mason, J. M., Leikauf, G. D., Schulz, H. (2007). Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure. Physiol. Genomics 31: 410-421 [Abstract] [Full Text]  
• Chan, L. C., Peters, W., Xu, Y., Chun, J., Farese, R. V. Jr, Cases, S. (2007). LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J. Leukoc. Biol. 82: 1193-1200 [Abstract] [Full Text]  
• Murph, M. M., Hurst-Kennedy, J., Newton, V., Brindley, D. N., Radhakrishna, H. (2007). Lysophosphatidic Acid Decreases the Nuclear Localization and Cellular Abundance of the p53 Tumor Suppressor in A549 Lung Carcinoma Cells. Mol Cancer Res 5: 1201-1211 [Abstract] [Full Text]  
• Singh, A. D, Sisley, K., Xu, Y., Li, J., Faber, P., Plummer, S. J, Mudhar, H. S, Rennie, I. G, Kessler, P. M, Casey, G., Williams, B. G (2007). Reduced expression of autotaxin predicts survival in uveal melanoma. Br. J. Ophthalmol. 91: 1385-1392 [Abstract] [Full Text]  
• Xin, C., Ren, S., Eberhardt, W., Pfeilschifter, J., Huwiler, A. (2007). Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1{beta}-induced prostaglandin E2 formation. J. Lipid Res. 48: 1985-1996 [Abstract] [Full Text]  
• Zhao, Z., Xiao, Y., Elson, P., Tan, H., Plummer, S. J., Berk, M., Aung, P. P., Lavery, I. C., Achkar, J. P., Li, L., Casey, G., Xu, Y. (2007). Plasma Lysophosphatidylcholine Levels: Potential Biomarkers for Colorectal Cancer. JCO 25: 2696-2701 [Abstract] [Full Text]  
• Damirin, A., Tomura, H., Komachi, M., Liu, J.-P., Mogi, C., Tobo, M., Wang, J.-Q., Kimura, T., Kuwabara, A., Yamazaki, Y., Ohta, H., Im, D.-S., Sato, K., Okajima, F. (2007). Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 292: H2513-H2522 [Abstract] [Full Text]  
• Zhao, Y., He, D., Zhao, J., Wang, L., Leff, A. R., Spannhake, E. Wm., Georas, S., Natarajan, V. (2007). Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor {alpha}2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells. J. Biol. Chem. 282: 10172-10179 [Abstract] [Full Text]  
• Jeng, Y.-J., Suarez, V. R., Izban, M. G., Wang, H.-Q., Soloff, M. S. (2007). Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. Am. J. Physiol. Endocrinol. Metab. 292: E1110-E1121 [Abstract] [Full Text]  
• Lee, C.-W., Rivera, R., Dubin, A. E., Chun, J. (2007). LPA4/GPR23 Is a Lysophosphatidic Acid (LPA) Receptor Utilizing Gs-, Gq/Gi-mediated Calcium Signaling and G12/13-mediated Rho Activation. J. Biol. Chem. 282: 4310-4317 [Abstract] [Full Text]  
• Pilquil, C., Dewald, J., Cherney, A., Gorshkova, I., Tigyi, G., English, D., Natarajan, V., Brindley, D. N. (2006). Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation. J. Biol. Chem. 281: 38418-38429 [Abstract] [Full Text]  
• Ohkawa, R., Hisano, N., Nakamura, K., Okubo, S., Yokota, H., Yatomi, Y. (2006). Lysophospholipase D activity exists in the urine to catalyse the formation of lysophosphatidic acid. Nephrol Dial Transplant 21: 3612-3613 [Full Text]  
• Murph, M., Tanaka, T., Liu, S., Mills, G. B. (2006). Of Spiders and Crabs: The Emergence of Lysophospholipids and Their Metabolic Pathways as Targets for Therapy in Cancer.. Clin. Cancer Res. 12: 6598-6602 [Abstract] [Full Text]  
• Tsuda, S., Okudaira, S., Moriya-Ito, K., Shimamoto, C., Tanaka, M., Aoki, J., Arai, H., Murakami-Murofushi, K., Kobayashi, T. (2006). Cyclic Phosphatidic Acid Is Produced by Autotaxin in Blood. J. Biol. Chem. 281: 26081-26088 [Abstract] [Full Text]  
• Abbracchio, M. P., Burnstock, G., Boeynaems, J.-M., Barnard, E. A., Boyer, J. L., Kennedy, C., Knight, G. E., Fumagalli, M., Gachet, C., Jacobson, K. A., Weisman, G. A. (2006). International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy. Pharmacol. Rev. 58: 281-341 [Abstract] [Full Text]  
• Tanaka, M., Okudaira, S., Kishi, Y., Ohkawa, R., Iseki, S., Ota, M., Noji, S., Yatomi, Y., Aoki, J., Arai, H. (2006). Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid. J. Biol. Chem. 281: 25822-25830 [Abstract] [Full Text]  
• Baker, D. L., Fujiwara, Y., Pigg, K. R., Tsukahara, R., Kobayashi, S., Murofushi, H., Uchiyama, A., Murakami-Murofushi, K., Koh, E., Bandle, R. W., Byun, H.-S., Bittman, R., Fan, D., Murph, M., Mills, G. B., Tigyi, G. (2006). Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasis. J. Biol. Chem. 281: 22786-22793 [Abstract] [Full Text]  
• van Meeteren, L. A., Ruurs, P., Stortelers, C., Bouwman, P., van Rooijen, M. A., Pradere, J. P., Pettit, T. R., Wakelam, M. J. O., Saulnier-Blache, J. S., Mummery, C. L., Moolenaar, W. H., Jonkers, J. (2006). Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development.. Mol. Cell. Biol. 26: 5015-5022 [Abstract] [Full Text]  
• Kishi, Y., Okudaira, S., Tanaka, M., Hama, K., Shida, D., Kitayama, J., Yamori, T., Aoki, J., Fujimaki, T., Arai, H. (2006). Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid. J. Biol. Chem. 281: 17492-17500 [Abstract] [Full Text]  
• Ren, J., Xiao, Y.-j., Singh, L. S., Zhao, X., Zhao, Z., Feng, L., Rose, T. M., Prestwich, G. D., Xu, Y. (2006). Lysophosphatidic Acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.. Cancer Res. 66: 3006-3014 [Abstract] [Full Text]  
• Koike, S., Keino-Masu, K., Ohto, T., Masu, M. (2006). The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide. GENES CELLS 11: 133-142 [Abstract] [Full Text]  
• Baumforth, K. R. N., Flavell, J. R., Reynolds, G. M., Davies, G., Pettit, T. R., Wei, W., Morgan, S., Stankovic, T., Kishi, Y., Arai, H., Nowakova, M., Pratt, G., Aoki, J., Wakelam, M. J. O., Young, L. S., Murray, P. G. (2005). Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood 106: 2138-2146 [Abstract] [Full Text]  
• Jansen, S., Stefan, C., Creemers, J. W. M., Waelkens, E., Van Eynde, A., Stalmans, W., Bollen, M. (2005). Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. J. Cell Sci. 118: 3081-3089 [Abstract] [Full Text]  
• Sakagami, H., Aoki, J., Natori, Y., Nishikawa, K., Kakehi, Y., Natori, Y., Arai, H. (2005). Biochemical and Molecular Characterization of a Novel Choline-specific Glycerophosphodiester Phosphodiesterase Belonging to the Nucleotide Pyrophosphatase/Phosphodiesterase Family. J. Biol. Chem. 280: 23084-23093 [Abstract] [Full Text]  
• Maffucci, T., Cooke, F. T., Foster, F. M., Traer, C. J., Fry, M. J., Falasca, M. (2005). Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J. Cell Biol. 169: 789-799 [Abstract] [Full Text]  
• Bektas, M., Payne, S. G., Liu, H., Goparaju, S., Milstien, S., Spiegel, S. (2005). A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J. Cell Biol. 169: 801-811 [Abstract] [Full Text]  
• van Meeteren, L. A., Ruurs, P., Christodoulou, E., Goding, J. W., Takakusa, H., Kikuchi, K., Perrakis, A., Nagano, T., Moolenaar, W. H. (2005). Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine 1-Phosphate. J. Biol. Chem. 280: 21155-21161 [Abstract] [Full Text]  
• Huber, C., Thielen, C., Seeger, H., Schwarz, P., Montrasio, F., Wilson, M. R., Heinen, E., Fu, Y.-X., Miele, G., Aguzzi, A. (2005). Lymphotoxin-{beta} Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes. J. Immunol. 174: 5526-5536 [Abstract] [Full Text]  
• Allende, M. L., Sasaki, T., Kawai, H., Olivera, A., Mi, Y., van Echten-Deckert, G., Hajdu, R., Rosenbach, M., Keohane, C. A., Mandala, S., Spiegel, S., Proia, R. L. (2004). Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720. J. Biol. Chem. 279: 52487-52492 [Abstract] [Full Text]  
• Waggoner, D. W., Johnson, L. B., Mann, P. C., Morris, V., Guastella, J., Bajjalieh, S. M. (2004). MuLK, a Eukaryotic Multi-substrate Lipid Kinase. J. Biol. Chem. 279: 38228-38235 [Abstract] [Full Text]  
• Stossi, F., Barnett, D. H., Frasor, J., Komm, B., Lyttle, C. R., Katzenellenbogen, B. S. (2004). Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) {alpha} or ER{beta} in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors. Endocrinology 145: 3473-3486 [Abstract] [Full Text]  
• Palmeri, D., Zuo, F.-R., Rosen, S. D., Hemmerich, S. (2004). Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking. J. Leukoc. Biol. 75: 910-927 [Abstract] [Full Text]  
• Hama, K., Aoki, J., Fukaya, M., Kishi, Y., Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe, M., Chun, J., Arai, H. (2004). Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1. J. Biol. Chem. 279: 17634-17639 [Abstract] [Full Text]  
• van Meeteren, L. A., Frederiks, F., Giepmans, B. N. G., Pedrosa, M. F. F., Billington, S. J., Jost, B. H., Tambourgi, D. V., Moolenaar, W. H. (2004). Spider and Bacterial Sphingomyelinases D Target Cellular Lysophosphatidic Acid Receptors by Hydrolyzing Lysophosphatidylcholine. J. Biol. Chem. 279: 10833-10836 [Abstract] [Full Text]  
• Fang, X., Yu, S., Bast, R. C., Liu, S., Xu, H.-J., Hu, S.-X., LaPushin, R., Claret, F. X., Aggarwal, B. B., Lu, Y., Mills, G. B. (2004). Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells. J. Biol. Chem. 279: 9653-9661 [Abstract] [Full Text]  
• Yamada, T., Sato, K., Komachi, M., Malchinkhuu, E., Tobo, M., Kimura, T., Kuwabara, A., Yanagita, Y., Ikeya, T., Tanahashi, Y., Ogawa, T., Ohwada, S., Morishita, Y., Ohta, H., Im, D.-S., Tamoto, K., Tomura, H., Okajima, F. (2004). Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1. J. Biol. Chem. 279: 6595-6605 [Abstract] [Full Text]  
• Radu, C. G., Yang, L. V., Riedinger, M., Au, M., Witte, O. N. (2004). T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc. Natl. Acad. Sci. USA 101: 245-250 [Abstract] [Full Text]  
• Hiramatsu, T., Sonoda, H., Takanezawa, Y., Morikawa, R., Ishida, M., Kasahara, K., Sanai, Y., Taguchi, R., Aoki, J., Arai, H. (2003). Biochemical and Molecular Characterization of Two Phosphatidic Acid-selective Phospholipase A1s, mPA-PLA1{alpha} and mPA-PLA1{beta}. J. Biol. Chem. 278: 49438-49447 [Abstract] [Full Text]  
• Smyth, S. S., Sciorra, V. A., Sigal, Y. J., Pamuklar, Z., Wang, Z., Xu, Y., Prestwich, G. D., Morris, A. J. (2003). Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets: STUDIES USING CHEMICAL INHIBITORS OF LIPID PHOSPHATE PHOSPHATASE ACTIVITY. J. Biol. Chem. 278: 43214-43223 [Abstract] [Full Text]  
• Duan, R.-D., Bergman, T., Xu, N., Wu, J., Cheng, Y., Duan, J., Nelander, S., Palmberg, C., Nilsson, A. (2003). Identification of Human Intestinal Alkaline Sphingomyelinase as a Novel Ecto-enzyme Related to the Nucleotide Phosphodiesterase Family. J. Biol. Chem. 278: 38528-38536 [Abstract] [Full Text]  
• Ohta, H., Sato, K., Murata, N., Damirin, A., Malchinkhuu, E., Kon, J., Kimura, T., Tobo, M., Yamazaki, Y., Watanabe, T., Yagi, M., Sato, M., Suzuki, R., Murooka, H., Sakai, T., Nishitoba, T., Im, D.-S., Nochi, H., Tamoto, K., Tomura, H., Okajima, F. (2003). Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors. Mol. Pharmacol. 64: 994-1005 [Abstract] [Full Text]  
• Luquain, C., Singh, A., Wang, L., Natarajan, V., Morris, A. J. (2003). Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells. J. Lipid Res. 44: 1963-1975 [Abstract] [Full Text]  
• Stahle, M., Veit, C., Bachfischer, U., Schierling, K., Skripczynski, B., Hall, A., Gierschik, P., Giehl, K. (2003). Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK. J. Cell Sci. 116: 3835-3846 [Abstract] [Full Text]  
• Clair, T., Aoki, J., Koh, E., Bandle, R. W., Nam, S. W., Ptaszynska, M. M., Mills, G. B., Schiffmann, E., Liotta, L. A., Stracke, M. L. (2003). Autotaxin Hydrolyzes Sphingosylphosphorylcholine to Produce the Regulator of Migration, Sphingosine-1-Phosphate. Cancer Res. 63: 5446-5453 [Abstract] [Full Text]  
• Tanyi, J. L., Hasegawa, Y., Lapushin, R., Morris, A. J., Wolf, J. K., Berchuck, A., Lu, K., Smith, D. I., Kalli, K., Hartmann, L. C., McCune, K., Fishman, D., Broaddus, R., Cheng, K. W., Atkinson, E. N., Yamal, J. M., Bast, R. C., Felix, E. A., Newman, R. A., Mills, G. B. (2003). Role of Decreased Levels of Lipid Phosphate Phosphatase-1 in Accumulation of Lysophosphatidic Acid in Ovarian Cancer. Clin. Cancer Res. 9: 3534-3545 [Abstract] [Full Text]  
• Okusa, M. D., Ye, H., Huang, L., Sigismund, L., Macdonald, T., Lynch, K. R. (2003). Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 285: F565-F574 [Abstract] [Full Text]  
• Ferry, G., Tellier, E., Try, A., Gres, S., Naime, I., Simon, M. F., Rodriguez, M., Boucher, J., Tack, I., Gesta, S., Chomarat, P., Dieu, M., Raes, M., Galizzi, J. P., Valet, P., Boutin, J. A., Saulnier-Blache, J. S. (2003). Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation. UP-REGULATED EXPRESSION WITH ADIPOCYTE DIFFERENTIATION AND OBESITY. J. Biol. Chem. 278: 18162-18169 [Abstract] [Full Text]  
• Koh, E., Clair, T., Woodhouse, E. C., Schiffmann, E., Liotta, L., Stracke, M. (2003). Site-directed Mutations in the Tumor-associated Cytokine, Autotaxin, Eliminate Nucleotide Phosphodiesterase, Lysophospholipase D, and Motogenic Activities. Cancer Res. 63: 2042-2045 [Abstract] [Full Text]  
• Barden, C. B., Shister, K. W., Zhu, B., Guiter, G., Greenblatt, D. Y., Zeiger, M. A., Fahey, T. J. III (2003). Classification of Follicular Thyroid Tumors by Molecular Signature: Results of Gene Profiling. Clin. Cancer Res. 9: 1792-1800 [Abstract] [Full Text]  
• Zambonelli, C., Roberts, M. F. (2003). An Iron-dependent Bacterial Phospholipase D Reminiscent of Purple Acid Phosphatases. J. Biol. Chem. 278: 13706-13711 [Abstract] [Full Text]  
• McIntyre, T. M., Pontsler, A. V., Silva, A. R., St. Hilaire, A., Xu, Y., Hinshaw, J. C., Zimmerman, G. A., Hama, K., Aoki, J., Arai, H., Prestwich, G. D. (2003). From the Cover: Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl. Acad. Sci. USA 100: 131-136 [Abstract] [Full Text]  
• Aoki, J., Taira, A., Takanezawa, Y., Kishi, Y., Hama, K., Kishimoto, T., Mizuno, K., Saku, K., Taguchi, R., Arai, H. (2002). Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways. J. Biol. Chem. 277: 48737-48744 [Abstract] [Full Text]  
• Moolenaar, W. H. (2002). Lysophospholipids in the limelight: autotaxin takes center stage. J. Cell Biol. 158: 197-199 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents