Yersinia type III secretion: send in the effectors

doi:10.1083/jcb.200205077

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Published 5 August 2002. doi:10.1083/jcb.200205077

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© The Rockefeller University Press, 0021-9525/2002/8/401 $5.00
The Journal of Cell Biology, Volume 158, Number 3, August 5, 2002 401-408

Mini-Reviews

Yersinia type III secretion : send in the effectors

Guy R. Cornelis¹^,2

¹ Biozentrum der Universität Basel, CH-4056 Basel, Switzerland
² Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B 1200 Brussels, Belgium

Address correspondence to Guy R. Cornelis, Biozentrum der Universität Basel, Klingelbergstr. 50-70, CH-4056 Basel, Switzerland. Tel.: 41-61-267-21-10. Fax: 41-61-267-21-18. E-mail: guy.cornelis{at}unibas.ch

Abstract
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis,and Yersinia enterocolitica) have evolved an exquisite methodfor delivering powerful effectors into cells of the host immunesystem where they inhibit signaling cascades and block the cells'response to infection. Understanding the molecular mechanismsof this system has provided insight into the processes of phagocytosisand inflammation.

Key Words: bacterial pathogenesis; Yersinia; Yops; translocation; type III secretion

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