Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text PDF (Full Text) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Roy, C. R. Articles by Tilney, L. G. Search for Related Content PubMed PubMed Citation Articles by Roy, C. R. Articles by Tilney, L. G. Pubmed/NCBI databases Medline Plus Health Information Legionnaires' Disease Social Bookmarking                      What's this?

Craig R. Roy¹ and Lewis G. Tilney²

¹ Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536
² Department of Biology, University of Pennsylvania, Philadelphia, PA 19104

Address correspondence to Craig R. Roy, Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., New Haven, CT 06536. Tel.: (203) 737-2408. Fax: (203) 737-2630. E-mail: craig.roy{at}yale.edu

Abstract
Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in transporting Legionella to the ER.

Key Words: phagosome lysosome fusion; ADP ribosylation factor; type IV secretion; immune evasion; intracellular replication

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Kusner, D. J., Thompson, C. R., Melrose, N. A., Pitson, S. M., Obeid, L. M., Iyer, S. S. (2007). The Localization and Activity of Sphingosine Kinase 1 Are Coordinately Regulated with Actin Cytoskeletal Dynamics in Macrophages. J. Biol. Chem. 282: 23147-23162 [Abstract] [Full Text]  
• Molmeret, M., Santic', M., Asare, R., Carabeo, R. A., Kwaik, Y. A. (2007). Rapid Escape of the dot/icm Mutants of Legionella pneumophila into the Cytosol of Mammalian and Protozoan Cells. Infect. Immun. 75: 3290-3304 [Abstract] [Full Text]  
• Banga, S., Gao, P., Shen, X., Fiscus, V., Zong, W.-X., Chen, L., Luo, Z.-Q. (2007). Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc. Natl. Acad. Sci. USA 104: 5121-5126 [Abstract] [Full Text]  
• Fernandez-Moreira, E., Helbig, J. H., Swanson, M. S. (2006). Membrane Vesicles Shed by Legionella pneumophila Inhibit Fusion of Phagosomes with Lysosomes.. Infect. Immun. 74: 3285-3295 [Abstract] [Full Text]  
• Appelberg, R. (2006). Macrophage nutriprive antimicrobial mechanisms. J. Leukoc. Biol. 79: 1117-1128 [Abstract] [Full Text]  
• Sporri, R., Joller, N., Albers, U., Hilbi, H., Oxenius, A. (2006). MyD88-Dependent IFN-{gamma} Production by NK Cells Is Key for Control of Legionella pneumophila Infection. J. Immunol. 176: 6162-6171 [Abstract] [Full Text]  
• Abu-Zant, A., Santic, M., Molmeret, M., Jones, S., Helbig, J., Abu Kwaik, Y. (2005). Incomplete Activation of Macrophage Apoptosis during Intracellular Replication of Legionella pneumophila. Infect. Immun. 73: 5339-5349 [Abstract] [Full Text]  
• Fortier, A., Min-Oo, G., Forbes, J., Lam-Yuk-Tseung, S., Gros, P. (2005). Single gene effects in mouse models of host: pathogen interactions. J. Leukoc. Biol. 77: 868-877 [Abstract] [Full Text]  
• Touret, N., Paroutis, P., Grinstein, S. (2005). The nature of the phagosomal membrane: endoplasmic reticulum versus plasmalemma. J. Leukoc. Biol. 77: 878-885 [Abstract] [Full Text]  
• Molmeret, M., Horn, M., Wagner, M., Santic, M., Abu Kwaik, Y. (2005). Amoebae as Training Grounds for Intracellular Bacterial Pathogens. Appl. Environ. Microbiol. 71: 20-28 [Full Text]  
• Fajardo, M., Schleicher, M., Noegel, A., Bozzaro, S., Killinger, S., Heuner, K., Hacker, J., Steinert, M. (2004). Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum. Microbiology 150: 2825-2835 [Abstract] [Full Text]  
• Ohnishi, H., Mizunoe, Y., Takade, A., Tanaka, Y., Miyamoto, H., Harada, M., Yoshida, S.-i. (2004). Legionella dumoffii DjlA, a Member of the DnaJ Family, Is Required for Intracellular Growth. Infect. Immun. 72: 3592-3603 [Abstract] [Full Text]  
• Cossart, P., Sansonetti, P. J. (2004). Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens. Science 304: 242-248 [Abstract] [Full Text]  
• Yeo, H.-J., Waksman, G. (2004). Unveiling Molecular Scaffolds of the Type IV Secretion System. J. Bacteriol. 186: 1919-1926 [Full Text]  
• Luo, Z.-Q., Isberg, R. R. (2004). Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc. Natl. Acad. Sci. USA 101: 841-846 [Abstract] [Full Text]  
• Yeo, H.-J., Yuan, Q., Beck, M. R., Baron, C., Waksman, G. (2003). Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101. Proc. Natl. Acad. Sci. USA 100: 15947-15952 [Abstract] [Full Text]  
• Celli, J., de Chastellier, C., Franchini, D.-M., Pizarro-Cerda, J., Moreno, E., Gorvel, J.-P. (2003). Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum. J. Exp. Med. 198: 545-556 [Abstract] [Full Text]  
• Galan, J. E. (2002). The cell biology of microbial infections: coming of age. J. Cell Biol. 158: 387-388 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents