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Published 30 September 2002. doi:10.1083/jcb.200205028
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© The Rockefeller University Press, 0021-9525/2002/9/1183 $5.00
The Journal of Cell Biology, Volume 158, Number 7, September 30, 2002 1183-1193

Article

 Functional role of {varepsilon}-tubulin in the assembly of the centriolar microtubule scaffold

Pascale Dupuis-Williams1, Anne Fleury-Aubusson2, Nicole Garreau de Loubresse3, Hélène Geoffroy1, Laurence Vayssié1, Angélique Galvani1, Aude Espigat1 and Jean Rossier1

1 Laboratoire de Neurobiologie, UMR 7637 Centre National de la Recherche Scientifique, 75005 Paris, France
2 Laboratoire de Biologie Cellulaire 4, UPRESA 8080, Université Paris XI, 91405 Orsay cedex, France
3 Centre de Génétique Moléculaire, 91198 Gif-sur-Yvette cedex, France

Address correspondence to Pascale Dupuis-Williams, UMR 7637 Centre National de la Recherche Scientifique, ESPCI, 10 rue Vauquelin, 75231 Paris cedex 05, France. Tel.: 33-1-40794769. Fax: 33-1-40794757. E-mail: pascale.williams{at}espci.fr

Centrioles and basal bodies fascinate by their spectacular architecture, featuring an arrangement of nine microtubule triplets into an axial symmetry, whose biogenesis relies on yet elusive mechanisms. However, the recent discovery of new tubulins, such as {delta}-, {varepsilon}-, or {eta}-tubulin, could constitute a breakthrough for deciphering the assembly steps of this unconventional microtubule scaffold. Here, we report the functional analysis in vivo of {varepsilon}-tubulin, based on gene silencing in Paramecium, which demonstrates that this protein, which localizes at the basal bodies, is essential for the assembly and anchorage of the centriolar microtubules.

Key Words: centriole duplication; basal body; tubulin; cytoskeleton; paramecium


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