Cajal bodies and coilin--moving towards function

doi:10.1083/jcb.200206111

Published 14 October 2002. doi:10.1083/jcb.200206111

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Cajal bodies and coilin—moving towards function

Stephen C. Ogg and Angus I. Lamond

Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH Scotland, United Kingdom

Address correspondence to Angus Lamond, Wellcome Trust Biocentre, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH Scotland, UK. Tel.: (44) 1382-345473. Fax: (44) 1382-345695. E-mail: a.i.lamond{at}dundee.ac.uk

Abstract
Many nuclear factors are concentrated within nonmembrane-boundsubnuclear bodies. The Cajal body is an example of a conservednuclear compartment that has been linked to molecular disease.Recent studies have shown Cajal bodies to be surprisingly mobileand offer clues about their function in the cell.

Key Words: Cajal bodies; nucleoli; coilin; nucleus; guide RNAs

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