Direct cadherin-activated cell signaling: a view from the plasma membrane

doi:10.1083/jcb.200208156

Published online 30 December 2002. doi:10.1083/jcb.200208156

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Direct cadherin-activated cell signaling : a view from the plasma membrane

Alpha S. Yap and Eva M. Kovacs

School for Biomedical Science and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072

Address correspondence to Alpha S. Yap, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia 4072. Tel.: 61-7-33654906. Fax: 61-7-33651766. E-mail: a.yap{at}mailbox.uq.edu.au

Classical cadherin adhesion molecules are key determinants ofcell recognition and tissue morphogenesis, with diverse effectson cell behavior. Recent developments indicate that classicalcadherins are adhesion-activated signaling receptors. In particular,early–immediate Rac signaling is emerging as a mechanismto coordinate cadherin–actin integration at the plasmamembrane.

Key Words: cadherin; Rac; actin cytoskeleton; Rho GTPase; PI3 kinase

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