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Published 10 November 2003. doi:10.1083/jcb.200309111
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*CALCIUM, ELEMENTAL
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© The Rockefeller University Press, 0021-9525/2003/11/441 $8.00
The Journal of Cell Biology, Volume 163, Number 3, 441-443

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 Calcium mobilization from mitochondria in synaptic transmitter release

Rosario Rizzuto

Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy

Address correspondence to Dr. Rosario Rizzuto Dept. of Experimental and Diagnostic Medicine, University of Ferrara, Via Borsari, 46 44100 Ferrara, Italy. Tel.: 39-0532-291-361. Fax: 39-0532-247-278. email: rzr{at}dns.unife.it

Mitochondria can rapidly accumulate and release Ca2+ upon cell stimulation. A paper by Yang and coworkers in this issue reports an unusual form of synaptic potentiation, dependent on Ca2+ release from mitochondria through the Na+/Ca2+ exchanger and triggered by Na+ entry through voltage-gated channels (Yang et al., 2003).

Abbreviations used in this paper: PKC, protein kinase C; PTP, permeability transition pore.


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