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Ronald D. Vale

Department of Cellular and Molecular Pharmacology and The Howard Hughes Medical Institute, University of California, San Francisco, CA 94107

Address correspondence to Ron Vale, Dept. of Cellular and Molecular Pharmacology, University of California, 1600 16th St., San Francisco, CA 94107. Tel.: (415) 476-6380. Fax: (415) 476-5233. email: vale{at}cmp.ucsf.edu

Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how "dynamic" single molecule measurements can synergize with "static" protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine.

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