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Published 24 November 2003. doi:10.1083/jcb.200310137
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© The Rockefeller University Press, 0021-9525/2003/11/693 $8.00
The Journal of Cell Biology, Volume 163, Number 4, 693-695

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 Breathing down the neck of Unc104

Linda Wordeman

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195

Address correspondence to Linda Wordeman, Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195. Tel.: (206) 543-4135. Fax: (206) 685-0619. email: worde{at}u.washington.edu

The Unc104/Kif1A class of kinesins transports synaptic vesicle precursors along microtubules with high speed and processivity that has been proposed to depend on reversible dimerization between two poorly motile monomers. In this issue, Al-Bassam et al. (2003) discover a structural basis for regulation of motility by reversible dimerization.

Key Words: Unc104; Kif1A; kinesin; neck; microtubule

Abbreviations used in this paper: FHA, forkhead associated; KHC, kinesin heavy chain.


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