Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text PDF (Full Text) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nguyen, C. Articles by Bibb, J. A. Search for Related Content PubMed PubMed Citation Articles by Nguyen, C. Articles by Bibb, J. A. Social Bookmarking                      What's this?

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 74390

Address correspondence to James A. Bibb, Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., NC5.410, Dallas, TX 75390-9070. Tel.: (214) 648-4168. Fax: (214) 648-1293. email: james.bibb{at}utsouthwestern.edu

Regulation of endocytosis by protein phosphorylation and dephosphorylation is critical to synaptic vesicle recycling. Two groups have now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of this process. Robinson and coworkers recently demonstrated that Cdk5 is necessary for synaptic vesicle endocytosis (SVE) (Tan et al., 2003), whereas a new report in this issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003). Careful examination of the data reveals a model that helps resolve the apparently contradictory nature of these reports.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Amin, N. D., Zheng, Y.-L., Kesavapany, S., Kanungo, J., Guszczynski, T., Sihag, R. K., Rudrabhatla, P., Albers, W., Grant, P., Pant, H. C. (2008). Cyclin-Dependent Kinase 5 Phosphorylation of Human Septin SEPT5 (hCDCrel-1) Modulates Exocytosis. J. Neurosci. 28: 3631-3643 [Abstract] [Full Text]  
• Nguyen, C., Nishi, A., Kansy, J. W., Fernandez, J., Hayashi, K., Gillardon, F., Hemmings, H. C. Jr., Nairn, A. C., Bibb, J. A. (2007). Regulation of Protein Phosphatase Inhibitor-1 by Cyclin-dependent Kinase 5. J. Biol. Chem. 282: 16511-16520 [Abstract] [Full Text]  
• Graham, M. E., Anggono, V., Bache, N., Larsen, M. R., Craft, G. E., Robinson, P. J. (2007). The in Vivo Phosphorylation Sites of Rat Brain Dynamin I. J. Biol. Chem. 282: 14695-14707 [Abstract] [Full Text]  
• Fu, A. K. Y., Ip, F. C. F., Fu, W.-Y., Cheung, J., Wang, J. H., Yung, W.-H., Ip, N. Y. (2005). Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc. Natl. Acad. Sci. USA 102: 15224-15230 [Abstract] [Full Text]  
• Barclay, J. W., Aldea, M., Craig, T. J., Morgan, A., Burgoyne, R. D. (2004). Regulation of the Fusion Pore Conductance during Exocytosis by Cyclin-dependent Kinase 5. J. Biol. Chem. 279: 41495-41503 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents