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Published 22 December 2003. doi:10.1083/jcb.200306067
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© The Rockefeller University Press, 0021-9525/2003/12/1351 $8.00
The Journal of Cell Biology, Volume 163, Number 6, 1351-1362

Article

 {alpha}3ß1 integrin–CD151, a component of the cadherin–catenin complex, regulates PTPµ expression and cell–cell adhesion

Nibedita Chattopadhyay1,2, Zemin Wang1,2, Leonie K. Ashman3, Susann M. Brady-Kalnay4 and Jordan A. Kreidberg1,2

1 Department of Medicine, Children's Hospital
2 Department of Pediatrics, Harvard Medical School, Boston, MA 02115
3 School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
4 Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106

Address correspondence to Jordan Kreidberg, Division of Nephrology, Hunnewell 3, Children's Hospital, 300 Longwood Ave., Boston, MA 02115. Tel.: (617) 247-5194. Fax: (617) 232-4315. email: Jordan.Kreidberg{at}tch.harvard.edu

The ß1 family of integrins has been primarily studied as a set of receptors for the extracellular matrix. In this paper, we define a novel role for {alpha}3ß1 integrin in association with the tetraspanin CD151 as a component of a cell–cell adhesion complex in epithelial cells that directly stimulates cadherin-mediated adhesion. The integrin–tetraspanin complex affects epithelial cell–cell adhesion at the level of gene expression both by regulating expression of PTPµ and by organizing a multimolecular complex containing PKCßII, RACK1, PTPµ, ß-catenin, and E-cadherin. These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior.

Key Words: cell contact; tetraspanin; phosphatase; tyrosine phosphorylation; PKCßII

The online version of this article contains supplemental material.

Abbreviation used in this paper: shRNA, small hairpin RNA.


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