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Epitomics: The Rabbit Monoclonal Company
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Published 5 January 2004. doi:10.1083/jcb.200311102
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 164, Number 1, 15-17
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 Nuclear stress granules : the awakening of a sleeping beauty?



Anton Sandqvist1,2 and Lea Sistonen1,3

1 Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FIN-20521 Turku, Finland
2 Department of Biochemistry and Pharmacy and 3 Department of Biology, Åbo Akademi University, FIN-20521 Turku, Finland

Address correspondence to Lea Sistonen, Turku Centre for Biotechnology, BioCity, P.O. Box 123, FIN-20521 Turku, Finland. Tel.: 358-2-333-8028. Fax: 358-2-333-8000. email: lea.sistonen{at}btk.utu.fi

Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites, a heterochromatic region that has been considered silent (Jolly et al., 2004). These intriguing findings will certainly give the research of these structures a new twist.

Abbreviations used in this paper: HAP, hnRNP A1–associated protein; HSF1, heat shock factor 1.


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