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¹ Institute of Microbiology and Molecular Biology, University of Hohenheim, 70599 Stuttgart, Germany
² Department of Chemistry, The Ohio State University, Columbus, OH 43210

Address correspondence to Ross E. Dalbey, Dept. of Chemistry, The Ohio State University, 100 West 18th Ave., Columbus, OH 43210. Tel.: (614) 292-2384. Fax: (614) 292-1685. email: dalbey{at}chemistry.ohio-state.edu

Abstract
Members of the YidC family exist in all three domains of life, where they control the assembly of a large variety of membrane protein complexes that function as transporters, energy devices, or sensor proteins. Recent studies in bacteria have shown that YidC functions on its own as a membrane protein insertase independent of the Sec protein–conducting channel. YidC can also assist in the lateral integration and folding of membrane proteins that insert into the membrane via the Sec pathway.

Key Words: translocation; Oxa1; Alb3

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