Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text PDF (Full Text) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kowalczyk, A. Articles by Kaczmarek, L. Search for Related Content PubMed PubMed Citation Articles by Kowalczyk, A. Articles by Kaczmarek, L. Related Collections Related Article Social Bookmarking                      What's this?

¹ Department of Molecular and Cellular Neurobiology, Nencki Institute, 02-093 Warsaw, Poland
² Mossakowski Medical Research Centre, 02-106 Warsaw, Poland
³ Department of Pathology, Medical University of Warsaw, 02-106 Warsaw, Poland
⁴ Department of Cancer Biology, Dana-Farber Cancer Institute
⁵ Department of Pathology, Harvard Medical School, Boston, MA 02115

Correspondence to L. Kaczmarek: leszek{at}nencki.gov.pl

Abstract
Adult neurogenesis (i.e., proliferation and differentiation of neuronal precursors in the adult brain) is responsible for adding new neurons in the dentate gyrus of the hippocampus and in the olfactory bulb. We describe herein that adult mice mutated in the cell cycle regulatory gene Ccnd2, encoding cyclin D2, lack newly born neurons in both of these brain structures. In contrast, genetic ablation of cyclin D1 does not affect adult neurogenesis. Furthermore, we show that cyclin D2 is the only D-type cyclin (out of D1, D2, and D3) expressed in dividing cells derived from neuronal precursors present in the adult hippocampus. In contrast, all three cyclin D mRNAs are present in the cultures derived from 5-day-old hippocampi, when developmental neurogenesis in the dentate gyrus takes place. Thus, our results reveal the existence of molecular mechanisms discriminating adult versus developmental neurogeneses.

A. Kowalczyk and R.K. Filipkowski contributed equally to this paper.

M.A. Ciemerych's present address is Dept. of Embryology, Institute of Zoology, Warsaw University, 02-096 Warsaw, Poland.

Abbreviations used in this paper: DG, dentate gyrus; OB, olfactory bulb; SGZ, subgranular zone; WT, wild-type.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

One cyclin for adult neurogenesis

Rabiya Tuma
J. Cell Biol. 2004 167: 188. [Full Text] [PDF]

This article has been cited by other articles:

• Ferraiuolo, L., Heath, P. R., Holden, H., Kasher, P., Kirby, J., Shaw, P. J. (2007). Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALS. J. Neurosci. 27: 9201-9219 [Abstract] [Full Text]  
• Benes, F. M., Lim, B., Matzilevich, D., Walsh, J. P., Subburaju, S., Minns, M. (2007). Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. USA 104: 10164-10169 [Abstract] [Full Text]  
• Glickstein, S. B., Alexander, S., Ross, M. E. (2007). Differences in Cyclin D2 and D1 Protein Expression Distinguish Forebrain Progenitor Subsets. Cereb Cortex 17: 632-642 [Abstract] [Full Text]  
• Sundberg, M., Savola, S., Hienola, A., Korhonen, L., Lindholm, D. (2006). Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through ubiquitin-mediated degradation of cyclin D1.. J. Neurosci. 26: 5402-5410 [Abstract] [Full Text]  
• Teo, J.-L., Ma, H., Nguyen, C., Lam, C., Kahn, M. (2005). Specific inhibition of CBP/{beta}-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc. Natl. Acad. Sci. USA 102: 12171-12176 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents