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Epitomics: The Rabbit Monoclonal Company
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Published 14 February 2005. doi:10.1083/jcb.200411122
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 168, Number 4, 533-536
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 Cellular organization by self-organization : mechanisms and models for Min protein dynamics



Martin Howard1 and Karsten Kruse2

1 Department of Mathematics, Imperial College London, London SW7 2AZ, England, UK
2 Max-Planck-Institut für Physik komplexer Systeme, 01187 Dresden, Germany

Correspondence to M. Howard: martin.howard{at}imperial.ac.uk; or K. Kruse: karsten{at}mpipks-dresden.mpg.de


Abstract
We use the oscillating Min proteins of Escherichia coli as a prototype system to illustrate the current state and potential of modeling protein dynamics in space and time. We demonstrate how a theoretical approach has led to striking new insights into the mechanisms of self-organization in bacterial cells and indicate how these ideas may be applicable to more complex structure formation in eukaryotic cells.


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