JCB logo
R&D Systems
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 31 May 2005. doi:10.1083/jcb.200408005
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 169, Number 5, 789-799
This Article
Right arrow Full Text
Right arrow PDF (Full Text)
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maffucci, T.
Right arrow Articles by Falasca, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maffucci, T.
Right arrow Articles by Falasca, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Article

 Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

Tania Maffucci1, Frank T. Cooke2, Fiona M. Foster3, Colin J. Traer3, Michael J. Fry3, and Marco Falasca1

1 Department of Medicine, The Sackler Institute, University College London, London WC1E 6JJ, England, UK
2 Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, England, UK
3 School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, England, UK

Correspondence to Marco Falasca: m.falasca{at}ucl.ac.uk

The lipid products of phosphoinositide 3-kinase (PI3K) are involved in many cellular responses such as proliferation, migration, and survival. Disregulation of PI3K-activated pathways is implicated in different diseases including cancer and diabetes. Among the three classes of PI3Ks, class I is the best characterized, whereas class II has received increasing attention only recently and the precise role of these isoforms is unclear. Similarly, the role of phosphatidylinositol-3-phosphate (PtdIns-3-P) as an intracellular second messenger is only just beginning to be appreciated. Here, we show that lysophosphatidic acid (LPA) stimulates the production of PtdIns-3-P through activation of a class II PI3K (PI3K-C2ß). Both PtdIns-3-P and PI3K-C2ß are involved in LPA-mediated cell migration. This study is the first identification of PtdIns-3-P and PI3K-C2ß as downstream effectors in LPA signaling and demonstration of an intracellular role for a class II PI3K. Defining this novel PI3K-C2ß–PtdIns-3-P signaling pathway may help clarify the process of cell migration and may shed new light on PI3K-mediated intracellular events.

Abbreviations used in this paper: LPA, lysophosphatidic acid; PI3K, phosphoinositide 3-kinase; PLC, phospholipase C; PtdIns-3,4,5-P3, phosphatidylinositol-3,4,5-trisphosphate; PtdIns-3-P, phosphatidylinositol-3-phosphate.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents