Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion

doi:10.1083/jcb.200503129

Published online 13 June 2005. doi:10.1083/jcb.200503129
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 169, Number 6, 841-846

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Unzipped and loaded : the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion

Robert V. Skibbens

Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015

Correspondence to Robert V. Skibbens: rvs3{at}lehigh.edu

Abstract
It is well known that the products of chromosome replicationare paired to ensure that the sisters segregate away from eachother during mitosis. A key issue is how cells pair sister chromatidsbut preclude the catastrophic pairing of nonsister chromatids.The identification of both replication factor C and DNA helicasesas critical for sister chromatid pairing has brought new insightsinto this fundamental process.

Abbreviations used in this paper: PCNA, proliferating cell nuclearantigen; RFC, replication factor C.

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