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Published online 11 July 2005. doi:10.1083/jcb.200506039
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 170, Number 2, 169-171
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 It's HIP to be a hub : new trends for old-fashioned proteins



Manuela Vecchi1 and Pier Paolo Di Fiore1,2,3

1 Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) di Oncologia Molecolare, 20139 Milan, Italy
2 Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, 20122 Milan, Italy
3 Istituto Europeo di Oncologia, 20141 Milan, Italy

Correspondence to Pier Paolo Di Fiore: pierpaolo.difiore{at}ifom-ieo-campus.it


Abstract
Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.


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