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Published 10 October 2005. doi:10.1083/jcb.200508097
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 171, Number 1, 15-17
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 Aß generation in autophagic vacuoles

Noboru Mizushima

Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan

Correspondence to Noboru Mizushima: nmizu{at}rinshoken.or.jp


Abstract
Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of ß-amyloid (Aß) deposits called senile or neuritic plaques. Aß is generated by the proteolytic cleavage of Aß precursor protein (APP) by ß and {gamma}-secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of Aß peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains.

Abbreviations used in this paper: Aß, ß-amyloid; AD, Alzheimer's disease; APP, Aß precursor protein; AV, autophagic vacuole; PS1, presenilin-1.


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