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Cytokines in immune regulation
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Published 7 November 2005. doi:10.1083/jcb.200510105
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 171, Number 3, 415-417
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 Spying on IgE receptor signaling : simply complex, or not?



Derek Toomre

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520

Correspondence to derek.toomre{at}yale.edu


Abstract
Plasma membrane organization and the potential role, or not, of lipid raft microdomains in signal transduction is a controversial topic. Cross-correlation fluorescent correlation spectroscopy (CC-FCS) shows promise as a new approach to rapidly probe protein–protein interactions in living cells during signal transduction. CC-FCS data from studies of IgE receptor signaling challenge models of large stable lipid raft signaling domains and reveal a new complexity in the dynamic (re)organization of signaling complexes.

Abbreviations used in this paper: CC-FCS, cross-correlation fluorescent correlation spectroscopy; DRM, detergent-resistant membrane.


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