JCB logo
Sign up for e-mail content alerts
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 28 November 2005. doi:10.1083/jcb.200510127
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 171, Number 5, 761-763
This Article
Right arrow Full Text
Right arrow PDF (Full Text)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thorne, M. E.
Right arrow Articles by Gottardi, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thorne, M. E.
Right arrow Articles by Gottardi, C. J.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Comment

 Terminating Wnt signals : a novel nuclear export mechanism targets activated ß-catenin



Meghan E. Thorne3 and Cara J. Gottardi1,2

1 Department of Medicine, Northwestern University, Chicago, IL 60637
2 Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60637
3 The Integrated Graduate Program in the Life Sciences, Northwestern University, Chicago, IL 60637

Correspondence to Cara J. Gottardi: c-gottardi{at}northwestern.edu


Abstract
Nuclear targeting of ß-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes ß-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of ß-catenin. We speculate that cells may use multiple export mechanisms to inhibit ß-catenin signaling in different ways.

Abbreviations used in this paper: APC, adenomatous polyposis coli; CRM1, exportin chromosome region maintenance 1; GSK3ß, glycogen synthase kinase 3ß; RanBP3, Ran binding protein 3; TCF, T cell factor.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents