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Published online 6 March 2006. doi:10.1083/jcb.200512082
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 172, Number 6, 803-808
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Mini-Review

RNA granules

Paul Anderson and Nancy Kedersha

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115

Correspondence to Nancy Kedersha: nkedersha{at}rics.bwh.Harvard.edu; or Paul Anderson: panderson{at}rics.bwh.Harvard.edu


Abstract
Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold proteins, and RNA-binding proteins, and they control the localization, stability, and translation of their RNA cargo. We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay.

Abbreviations used in this paper: GCG, germ cell granule; miRNA, microRNA; PB, processing body; SG, stress granule.


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