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Published 19 June 2006. doi:10.1083/jcb.200605150
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 173, Number 6, 829-831
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 "HURP on" we're off to the kinetochore!

Andrew Wilde

Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Correspondence to Andrew Wilde: andrew.wilde{at}utoronto.ca

RanGTP has a central role in spindle assembly, but the Ran-regulated factors required to initiate spindle bipolarity and stabilize MT growth toward the chromosomes remain unknown. However, three recent papers (Koffa et al., 2006; Sillje et al., 2006; Wong and Fang, 2006) have identified a single factor, HURP, that may encompass both of these properties.

Abbreviations used in this paper: HURP, hepatoma up-regulated protein; MT, microtubule.


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