JCB logo
PeproTech: Your source for Cell Biology Research Reagents
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 26 June 2006. doi:10.1083/jcb.200601089
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 174, Number 1, 141-151
This Article
Right arrow Full Text
Right arrow PDF (Full Text)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Togashi, H.
Right arrow Articles by Takeichi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Togashi, H.
Right arrow Articles by Takeichi, M.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*Nucleotide
*Protein*UniGene
Related Collections
Right arrowRelated Articles
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Article

 Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery

Hideru Togashi1,2, Jun Miyoshi4, Tomoyuki Honda3, Toshiaki Sakisaka3, Yoshimi Takai3, and Masatoshi Takeichi1,2

1 RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan
2 Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
3 Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Osaka 565-0871, Japan
4 Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka 537-8511, Japan

Correspondence to Masatoshi Takeichi: takeichi{at}cdb.riken.jp

Neurites recognize their specific partners during the formation of interneuronal connections. In hippocampal pyramidal neurons, axons attach to dendrites for their synaptogenesis, but the dendrites do not form stable contacts with each other, suggesting the presence of a mechanism to allow their selective associations. Nectin-1 (N1), an immunoglobulin domain adhesive protein, is preferentially localized in axons, and its heterophilic partner, N3, is present in both axons and dendrites; we tested their potential roles in interneurite recognition. The overexpression of N1, causing its mislocalization to dendrites, induced atypical dendrodendritic as well as excessive axodendritic associations. On the contrary, the genetic deletion of N1 loosened the contacts between axons and dendritic spines. Those actions of nectins required cadherin–catenin activities, but the overexpression of cadherin itself could not accelerate neurite attachment. These results suggest that the axon-biased localization of N1 and its trans-interaction with N3 in cooperation with the cadherin machinery is critical for the ordered association of axons and dendrites.

Abbreviations used in this paper: CP, cytoplasmic; DIV, days in vitro; EC, extracellular.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Articles

Con-nectin axons and dendrites
Gerard M.J. Beaudoin, III
J. Cell Biol. 2006 174: 7-9. [Abstract] [Full Text] [PDF]

Opposites attract
Rabiya S. Tuma
J. Cell Biol. 2006 174: 2a. [Full Text] [PDF]



This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents